Serum 25-hydroxyvitamin D and the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study
Alonso A, Misialek JR, Michos ED, Eckfeldt J, Selvin E, Soliman EZ, Chen LY, Gross MD, Lutsey PL
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 30 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Heart Association
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NIDDK NIH HHS
- Government
- National Heart, Lung and Blood Institute
- Nonprofit
- American Heart Association-American Stroke Association
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (HHSN268201 100012C); National Institute of Diabetes and Digestive and Kidney Diseases (K24-DK-106414); National Heart, Lung, and Blood Institute (R01 HL103706); National Heart, Lung, and Blood Institute (HHSN268201100007C); National Institute of Diabetes and Digestive and Kidney Diseases (R01NS072243); National Heart, Lung, and Blood Institute (HHSN2682 01100008C); National Heart, Lung, and Blood Institute (HH-SN-268201100006C); National Heart, Lung, and Blood Institute (HHSN268201100011C); National Heart, Lung, and Blood Institute (HHSN268201100005C); National Heart, Lung, and Blood Institute (HHSN268201100010C); American Heart Association (16EIA26410001); National Heart, Lung, and Blood Institute (HHSN26820 1100009C); National Heart, Lung, and Blood Institute (R01DK089174); National Heart, Lung, and Blood Institute (R01HL103706-S1); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK089174)
Based on 8 listed funder(s).
Publication
- Published
- 2016-02-03 · Europace · vol. 18 · issue 8 · pp. 1143–1149
- Publisher
- Oxford University Press
- Cited
- 34 citations · more than 88% of similar papers · 2.5× the field average
- References
- 20 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Cardiovascular Disease and Adiposity · Cardiac Imaging and Diagnostics
- Keywords
- Medicine, Hazard ratio, Atrial fibrillation, Internal medicine, Prospective cohort study, Atherosclerosis Risk in Communities, Proportional hazards model, Incidence (geometry), Confidence interval, Cardiology, Gastroenterology
- MeSH
- humans, atrial fibrillation, vitamin d, incidence, multivariate analysis, proportional hazards models, risk factors, middle aged, united states, female, male, mass spectrometry
9 authors
From US
- Álvaro Alonso · correspondingUniversity of Minnesota
- Jeffrey R. MisialekUniversity of Minnesota
- Erin D. MichosJohns Hopkins University; Johns Hopkins Medicine
- John H. EckfeldtUniversity of Minnesota Medical Center
- Elizabeth SelvinJohns Hopkins University
- Elsayed Z. SolimanWake Forest University
Abstract
Aims
To assess the prospective association between circulating 25-hydroxyvitamin D [25(OH)D] and atrial fibrillation (AF) risk.
Methods and results
We studied 12 303 participants from the Atherosclerosis Risk in Communities study without baseline AF (1990-92). Baseline serum total 25(OH)D was measured using mass spectrometry. Incident AF cases were identified from electrocardiograms, hospital discharge codes, and death certificates through 2012. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) of AF across clinical categories of serum 25(OH)D concentrations with multivariable Cox models, and tested interactions by age, race, and sex. We meta-analysed our results with those from published prospective studies that reported associations between 25(OH)D and AF risk. During a median follow-up of 21 years, we identified 1866 AF events. In multivariable models, deficient 25(OH)D status ( 0.40), was identified, with higher risk of AF among those with deficient 25(OH)D status in younger (HR, 95% CI: 1.35, 1.05-1.73) but not older individuals (HR, 95% CI: 1.02, 0.86-1.21). A meta-analysis of these results and four prospective studies did not support a clinically relevant association of circulating 25(OH)D with AF risk [pooled HR, 95%CI: 1.04, 1.00-1.08, per 1 SD lower 25(OH)D].
Conclusion
Low serum 25(OH)D was not associated with incident AF in a community-based cohort and in a meta-analysis of prospective studies. A possible association in younger individuals warrants further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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