Extra-Virgin Olive Oil Reduces Glycemic Response to a High-Glycemic Index Meal in Patients With Type 1 Diabetes: A Randomized Controlled Trial
Bozzetto L, Alderisio A, Giorgini M, Barone F, Giacco A, Riccardi G, Rivellese AA, Annuzzi G
Diabetes care · 44 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Ministero Istruzione Università e Ricerca
Based on 1 listed funder(s).
Publication
- Published
- 2016-02-09 · Diabetes Care · vol. 39 · issue 4 · pp. 518–524
- Publisher
- American Diabetes Association
- Cited
- 76 citations · more than 95% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 28 works
- Access
- Free to read
- Research areas
- Diabetes Management and Research · Nutritional Studies and Diet · Bariatric Surgery and Outcomes
- Keywords
- Postprandial, Medicine, Glycemic index, Crossover study, Context (archaeology), Meal, Glycemic, Type 2 diabetes, Internal medicine, Insulin, Carbohydrate, Diabetes mellitus, Endocrinology, Olive oil, Area under the curve, Food science, Placebo, Chemistry, Biology
- MeSH
- humans, diabetes mellitus, type 1, insulin, blood glucose, body mass index, treatment outcome, cross-over studies, sample size, glycemic index, postprandial period, adult, middle aged, female, male, meals, olive oil, glycated hemoglobin
8 authors
From IT
- Lutgarda BozzettoUniversity of Naples Federico II
- Antonio AlderisioUniversity of Naples Federico II
- Marisa GiorginiUniversity of Naples Federico II
- Francesca BaroneUniversity of Naples Federico II
- Angela GiaccoUniversity of Naples Federico II
- Gabriele RiccardiUniversity of Naples Federico II
Abstract
Objective
To evaluate whether fat quality, in the context of meals with high- (HGI) or low-glycemic index (LGI), influences postprandial blood glucose (PPG) response in patients with type 1 diabetes.
Research design and methods
According to a randomized crossover design, 13 patients with type 1 diabetes on insulin pump consumed two series (HGI or LGI) of meals with the same carbohydrate quantity while differing for amount and quality of fat: 1) low in fat ("low fat"), 2) high in saturated fat (butter), or 3) high in monounsaturated fat (extra-virgin olive oil) (EVOO). Premeal insulin doses were based on insulin-to-glycemic load ratios. Continuous glucose monitoring was performed and 6-h PPG evaluated.
Results
PPG was significantly different between HGI and LGI meals (P = 0.005 for time × glycemic index interaction by repeated-measures analysis [RMA]), being significantly higher during the first 3 h after the HGI meals with a later tendency to an opposite pattern. In the context of HGI meals, PPG was significantly lower after EVOO than after low fat or butter (P < 0.0001 for time × meal interaction by RMA), with a marked difference in the 0- to 3-h glucose incremental area under the curve between EVOO (mean ± SD 198 ± 274 mmol/L × 180 min) and either low fat (416 ± 329) or butter (398 ± 355) (P < 0.05). No significant differences were observed in PPG between the three LGI meals.
Conclusions
Carbohydrate quality of a mixed meal influences shape and extent of PPG. Besides, using EVOO in a HGI meal attenuates the early postprandial glucose response observed when this meal is consumed with either low fat or butter. Therefore, an optimal prandial insulin administration would require considering, in addition to the quantity of carbohydrates, the quality of both carbohydrate and fat.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.