Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia
Góralczyk K, Szymańska J, Szot K, Fisz J, Rość D
Lasers in medical science · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-02-09 · Lasers Med Sci · vol. 31 · issue 5 · pp. 825–831
- Publisher
- Springer Science+Business Media
- Cited
- 46 citations · more than 93% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 60 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Pain Management and Treatment
- Keywords
- Medicine, Umbilical vein, Low level laser therapy, Diabetes mellitus, Tumor necrosis factor alpha, Endothelial stem cell, Pathogenesis, Secretion, Internal medicine, Type 2 diabetes, Metabolic syndrome, Endocrinology, Laser therapy, Laser, Chemistry, In vitro
- MeSH
- umbilical veins, cell line, endothelial cells, humans, hyperglycemia, tumor necrosis factor-alpha, interleukin-6, cytokines, cell proliferation, low-level light therapy
5 authors
From PL
- Krzysztof Góralczyk · correspondingNicolaus Copernicus University; Collegium Medicum in Bydgoszcz
- Justyna SzymańskaNicolaus Copernicus University; Collegium Medicum in Bydgoszcz
- Katarzyna SzotNicolaus Copernicus University; Collegium Medicum in Bydgoszcz
- Jacek J. FiszNicolaus Copernicus University; Collegium Medicum in Bydgoszcz
- Danuta RośćNicolaus Copernicus University; Collegium Medicum in Bydgoszcz
Abstract
Diabetes mellitus is considered to be a very serious lifestyle disease leading to cardiovascular complications and impaired wound healing observed in the diabetic foot syndrome. Chronic hyperglycemia is the source of the endothelial activation. The inflammatory process in diabetes is associated with the secretion of inflammatory cytokines by endothelial cells, e.g., tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). The method of phototherapy using laser beam of low power (LLLT-low-level laser therapy) effectively supports the conventional treatment of diabetic vascular complications such as diabetic foot syndrome. The aim of our study was to evaluate the effect of low-power laser irradiation at two wavelengths (635 and 830 nm) on the secretion of inflammatory factors (TNF-α and IL-6) by the endothelial cell culture-HUVEC line (human umbilical vein endothelial cell)-under conditions of hyperglycemia. It is considered that adverse effects of hyperglycemia on vascular endothelial cells may be corrected by the action of LLLT, especially with the wavelength of 830 nm. It leads to the reduction of TNF-α concentration in the supernatant and enhancement of cell proliferation. Endothelial cells play an important role in the pathogenesis of diabetes; however, a small number of studies evaluate an impact of LLLT on these cells under conditions of hyperglycemia. Further work on this subject is warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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