Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women
Belury MA, Cole RM, Bailey BE, Ke JY, Andridge RR, Kiecolt-Glaser JK
Molecular nutrition & food research · 49 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NIH-NCI
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (R01 CA186720); National Cancer Institute (R01 CA186251); National Cancer Institute (R21 CA158868); National Cancer Institute (R21 CA154054); National Cancer Institute (K05 CA172296)
Based on 3 listed funder(s).
Publication
- Published
- 2016-02-29 · Mol Nutr Food Res · vol. 60 · issue 5 · pp. 1206–1212
- Publisher
- Wiley
- Cited
- 59 citations · more than 92% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (repository copy)
- Research areas
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Insulin resistance, Linoleic acid, Adipose tissue, Oleic acid, Internal medicine, Endocrinology, Composition (language), Lean body mass, Obesity, Fatty acid, Chemistry, Biology, Biochemistry, Medicine, Body weight
- MeSH
- erythrocytes, humans, insulin resistance, fatty acids, omega-3, linoleic acid, oleic acid, c-reactive protein, interleukin-6, body mass index, cohort studies, cross-sectional studies, body composition, dietary supplements, adult, middle aged, female, male
6 authors
From US
- Martha Ann Belury · correspondingNew York State University College of Human Ecology; The Ohio State University
- Rachel M. ColeNew York State University College of Human Ecology; The Ohio State University
- Brittney E. BaileyOhio Department of Health; Institute for Behavioral Medicine
- Jia‐Yu KeNew York State University College of Human Ecology; The Ohio State University
- Rebecca AndridgeOhio Department of Health
- Janice K. Kiecolt‐GlaserInstitute for Behavioral Medicine
Abstract
Scope
Supplementation with linoleic acid (LA; 18:2Ω6)-rich oils increases lean mass and decreases trunk adipose mass in people. Erythrocyte fatty acids reflect the dietary pattern of fatty acid intake and endogenous metabolism of fatty acids. The aim of this study is to determine the relationship of erythrocyte LA, with aspects of body composition, insulin resistance, and inflammation. Additionally, we tested for relationships of oleic acid (OA) and the sum of long chain omega-three fatty acids (LC-Ω3-SUM), on the same outcomes.
Methods and results
Men and women (N = 139) were evaluated for body composition, insulin resistance, and serum inflammatory markers, IL-6, and c-reactive protein (CRP) and erythrocyte fatty acid composition after an overnight fast. LA was positively related to appendicular lean mass/body mass index and inversely related to trunk adipose mass. Additionally, LA was inversely related to insulin resistance and IL-6. While there was an inverse relationship between OA or LC-Ω3-SUM with markers of inflammation, there were no relationships between OA or LC-Ω3-SUM with body composition or HOMA-IR.
Conclusion
Higher erythrocyte LA was associated with improved body composition, insulin resistance, and inflammation. Erythrocyte OA or LC-Ω3-SUM was unrelated to body composition and insulin resistance. There is much controversy about whether all unsaturated fats have the same benefits for metabolic syndrome and weight gain. We sought to test the strength of the relationships between three unsaturated fatty acid in erythrocytes with measurements of body composition, metabolism, and inflammation in healthy adults. Linoleic acid, but not oleic acid or the sum of long-chain omega 3 fatty acids (w3), was associated with increased appendicular lean mass and decreased trunk adipose mass and insulin resistance.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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