Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies
Lei Q, Zheng H, Bi J, Wang X, Jiang T, Gao X, Tian F, Xu M, Wu C, Zhang L, Li N, Li J
Medicine · 37 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2016-03-01 · Medicine (Baltimore) · vol. 95 · issue 9 · p. e2747
- Publisher
- Wolters Kluwer
- Cited
- 49 citations · more than 93% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (journal) · CC-BY-ND
- Research areas
- Pancreatic and Hepatic Oncology Research · Pancreatitis Pathology and Treatment · Esophageal and GI Pathology
- Keywords
- Medicine, Pancreatic cancer, Odds ratio, Subgroup analysis, Confidence interval, Internal medicine, Meta-analysis, Epidemiology, Gastroenterology, Cochrane Library, Cancer
- MeSH
- humans, pancreatic neoplasms, dietary fiber, protective factors, observational studies as topic, whole grains
12 authors
From CN
- Qiucheng LeiNanjing Medical University
- Huazhen ZhengGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Jingcheng BiGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Xinying Wang · correspondingGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Tingting Jiang · correspondingGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Xuejin GaoGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
Abstract
Mounting evidence from epidemiology studies suggests that whole grain intake may reduce pancreatic cancer risk, but convincing evidence is scarce. We conducted a meta-analysis to assess the association between whole grain intake and pancreatic cancer risk. Relevant observational studies were identified by searching PubMed, Embase, Scopus, and Cochrane library databases for the period from January 1980 to July 2015, with no restrictions. We calculated the summary odds ratios (ORs) for pancreatic cancer using random-effects model meta-analysis. Between-study heterogeneity was analyzed using the I statistic. A total of 8 studies regarding whole grain intake were included in the meta-analysis. The pooled OR of pancreatic cancer for those with high versus low whole grain intake was 0.76 (95% confidence interval [CI], 0.64-0.91; P = 0.002). There was no significant heterogeneity across these studies (I² = 11.7%; Pheterogeneity = 0.339). In the subgroup analysis by geographic area, the summary ORs of developing pancreatic cancer were 0.64 (95% CI, 0.53-0.79; P < 0.001; I ²= 0%; Pheterogeneity = 0.482) in the United States (n = 4) and 0.95 (95% CI, 0.63-1.43; P = 0.803; I ²= 45.6%; Pheterogeneity = 0.175) in Europe (n = 2). In the subgroup analysis by type of whole grain, the summary ORs were 0.72 (95% CI, 0.60-0.87; P = .001; I² = 0; Pheterogeneity = 0.876) for grains (n = 4) and 0.74 (95% CI, 0.27-2.02; P = 0.554; I² = 86.3%; Pheterogeneity = 0.007) for wheat (n = 2). A high intake of whole grains was associated with a reduced risk of pancreatic cancer. Because of the absent of more cohort studies, further prospective studies need to be conducted to ensure conclusions that are more robust.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-ND).
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