Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES
Anic GM, Albanes D, Rohrmann S, Kanarek N, Nelson WG, Bradwin G, Rifai N, McGlynn KA, Platz EA, Mondul AM
Clinical endocrinology · 36 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- New York City Department of Health and Mental Hygiene
- Government
- Maryland Department of Health and Mental Hygiene
- University or hospital
- Johns Hopkins University
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- Intramural NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (P30CA 006973); National Cancer Institute (CA006973); Johns Hopkins University (P30CA006973); National Institutes of Health (Z99 CA999999); National Institutes of Health (P30-CA006973); National Institutes of Health (CA006973)
Based on 7 listed funder(s).
Publication
- Published
- 2016-03-19 · Clin Endocrinol (Oxf) · vol. 85 · issue 2 · pp. 258–266
- Publisher
- Wiley
- Cited
- 47 citations · more than 93% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Hormonal and reproductive studies · Estrogen and related hormone effects
- Keywords
- National Health and Nutrition Examination Survey, Internal medicine, Sex hormone-binding globulin, Endocrinology, Vitamin D and neurology, Medicine, Testosterone (patch), Hormone, Prostate cancer, Body mass index, Confidence interval, Androgen, Population, Cancer
- MeSH
- adipose tissue, humans, prostatic neoplasms, gonadal steroid hormones, prostate-specific antigen, vitamin d, sex hormone-binding globulin, body mass index, cross-sectional studies, adult, male, waist circumference, ethnicity, racial groups
10 authors
From US, CH
- Gabriella M. AnicNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Demetrius AlbanesNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Sabine RohrmannUniversity of Zurich; Prevention Institute
- Norma KanarekJohns Hopkins University; Sidney Kimmel Comprehensive Cancer Center
- William G. NelsonJohns Hopkins University; Johns Hopkins Medicine; Sidney Kimmel Comprehensive Cancer Center
- Gary BradwinBoston Children's Hospital; Harvard University
Abstract
Background
Recent literature suggests that high circulating vitamin D may increase prostate cancer risk. Although the mechanism through which vitamin D may increase risk is unknown, vitamin D concentration could influence circulating sex steroid hormones that may be associated with prostate cancer; an alternate explanation is that it could be associated with prostate-specific antigen (PSA) concentration causing detection bias.
Objective
We examined whether serum vitamin D concentration was associated with sex steroid hormone and PSA concentrations in a cross-sectional analysis of men in the National Health and Nutrition Examination Surveys (NHANES).
Design
Testosterone, oestradiol, sex hormone-binding globulin (SHBG), androstanediol glucuronide, and 25-hydroxyvitamin D (25(OH)D) were measured in serum from men aged 20 and older participating in NHANES III (n = 1315) and NHANES 2001-2004 (n = 318). Hormone concentrations were compared across 25(OH)D quintiles, adjusting for age, race/ethnicity, body fat percentage, and smoking. PSA concentration was estimated by 25(OH)D quintile in 4013 men from NHANES 2001-2006.
Results
In NHANES III, higher testosterone (quintile (Q) 1 = 17·2, 95% confidence interval (CI) = 16·1-18·6; Q5 = 19·6, 95% CI = 18·7-20·6 nmol/l, P-trend = 0·0002) and SHBG (Q1 = 33·8, 95% CI = 30·8-37·0; Q5 = 38·4, 95% CI = 35·8-41·2 nmol/l, P-trend = 0·0005) were observed with increasing 25(OH)D. Similar results were observed in NHANES 2001-2004. PSA concentration was not associated with serum 25(OH)D (P-trend = 0·34).
Conclusion
Results from these nationally representative studies support a positive association between serum 25(OH)D and testosterone and SHBG. The findings support an indirect mechanism through which vitamin D may increase prostate cancer risk, and suggest the link to prostate cancer is not due to PSA-detection bias.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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