Brazil nut consumption modulates Nrf2 expression in hemodialysis patients: A pilot study
Cardozo LF, Stockler-Pinto MB, Mafra D
Molecular nutrition & food research · 49 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Based on 2 listed funder(s).
Publication
- Published
- 2016-03-19 · Mol Nutr Food Res · vol. 60 · issue 7 · pp. 1719–1724
- Publisher
- Wiley
- Cited
- 62 citations · more than 89% of similar papers · 2.8× the field average
- References
- 32 works
- Access
- Paywalled
- Research areas
- Nuts composition and effects · Selenium in Biological Systems · Curcumin's Biomedical Applications
- Keywords
- Malondialdehyde, Oxidative stress, Nut, Medicine, Peripheral blood mononuclear cell, Inflammation, Internal medicine, Hemodialysis, Endocrinology, Immunology, Food science, Chemistry, Biochemistry, In vitro
- MeSH
- leukocytes, mononuclear, humans, bertholletia, malondialdehyde, nad(p)h dehydrogenase (quinone), c-reactive protein, nf-kappa b, interleukin-6, body mass index, renal dialysis, pilot projects, oxidative stress, adult, aged, middle aged, female, male, nf-e2-related factor 2
3 authors
From BR
- L. Cardozo · correspondingUniversidade Federal Fluminense
- Milena Barcza Stockler‐PintoUniversidade Federal Fluminense
- Denise MafraUniversidade Federal Fluminense
Abstract
Scope
Previous studies showed that the supplementation with Brazil nut is effective in improving Se status, reduce oxidative stress, and inflammation in hemodialysis (HD) patients. As the nutritional compounds may promote the reduction of inflammation by activation of nuclear factor E2-related factor 2 (Nrf2), the aim of this pilot study was to evaluate the effects of Brazil nut supplementation on Nrf2 activation in HD patients.
Methods and results
Thirteen HD patients received one Brazil nut supplementation per day for 3 months and were compared to 12 HD patients without supplementation. Peripheral blood mononuclear cells were isolated and processed for expression of nuclear factor kappa B, Nrf2, and
Nad(p)h
quinone oxidoreductase 1 (NQO1) by quantitative real-time PCR. Plasma malondialdehyde, C-reactive protein and IL-6 levels were measured before and after supplementation. The Nrf2 expression increased and nuclear factor kappa B expression reducedpost supplementation. In addition, the cytokines and malondialdehyde levels decreased significantly. No significant alterations were found in the control group.
Conclusion
This preliminary result indicates the effectiveness of Brazil nut supplementation on human Nrf2 activation in HD patients and could be a possible explanation for the beneficial effects of this nut as a bioactive compound.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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