Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis
Upala S, Sanguankeo A
Photodermatology, photoimmunology & photomedicine · 43 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-03-23 · Photodermatol Photoimmunol Photomed · vol. 32 · issue 4 · pp. 181–190
- Publisher
- Wiley
- Cited
- 70 citations · more than 56% of similar papers · 0.8× the field average
- References
- 39 works
- Access
- Paywalled
- Research areas
- melanin and skin pigmentation · Vitamin D Research Studies · Acne and Rosacea Treatments and Effects
- Keywords
- Vitiligo, Medicine, Vitamin D and neurology, Meta-analysis, Observational study, vitamin D deficiency, Internal medicine, Confidence interval, Population, Gastroenterology, Dermatology, Environmental health
- MeSH
- humans, vitiligo, vitamin d, adult, female, male
2 authors
From TH, US
- Sikarin UpalaSiriraj Hospital; Mahidol University; Bassett Medical Center; Columbia University
- Anawin Sanguankeo · correspondingSiriraj Hospital; Mahidol University; Bassett Medical Center; Columbia University
Abstract
Background
Vitamin D deficiency is associated with a number of autoimmune diseases. We completed a meta-analysis of observational studies to establish whether there was a relationship between hypovitaminosis D and the autoimmune skin disease vitiligo.
Methods
Comprehensive search was applied in the MEDLINE and EMBASE databases from their inception to December 2015. Inclusion criteria were observational studies that assessed 25-hydroxyvitamin D (25(OH)D) levels in adults with vitiligo. The main outcome was the mean difference in serum 25(OH)D level between patients with vitiligo and controls.
Results
Our search strategy identified 383 articles; seventeen studies met the criteria for full-length review and seven studies, containing the data of 1200 patients, were included in a random-effects model meta-analysis. The pooled mean difference in serum 25-hydroxyvitamin D concentration between patients with vitiligo and controls was -7.45 ng/ml (95% confidence interval, -12.99 to -1.91, P-value = 0.01). The between-study heterogeneity (I(2) ) was 96%, P = value<0.001.
Conclusions
This meta-analysis identifies a significant relationship between low 25-hydroxyvitamin D levels and vitiligo, but does not prove causation. Our findings emphasize the importance of measuring 25-hydroxyvitamin D levels in patients with vitiligo. Further studies will be needed to establish whether vitamin D supplementation in this population improves the outcome of vitiligo.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.