Funded in part by Gatorade Sports Science Institute
Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men
McGlory C, Wardle SL, Macnaughton LS, Witard OC, Scott F, Dick J, Bell JG, Phillips SM, Galloway SD, Hamilton DL, Tipton KD
Physiological reports · 74 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Gatorade Sports Science Institute
- Unclassified
- Sporting Chance Initiative
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-03-01 · Physiol Rep · vol. 4 · issue 6 · p. e12715
- Publisher
- Wiley
- Cited
- 105 citations · more than 97% of similar papers · 5.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 30 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Sports Performance and Training · Cardiovascular and exercise physiology
- Keywords
- Anabolism, Ingestion, Endocrinology, Internal medicine, Medicine, Fish oil, Skeletal muscle, Biology, Fish <Actinopterygii>
- MeSH
- myofibrils, muscle, skeletal, humans, ribosomal protein s6 kinases, 70-kda, phospholipids, fish oils, muscle proteins, dietary proteins, anabolic agents, biopsy, treatment outcome, signal transduction, protein biosynthesis, phosphorylation, time factors, dietary supplements, scotland, male, proto-oncogene proteins c-akt, resistance training, amp-activated protein kinases, young adult
11 authors
From GB, CA
- Chris McGlory · correspondingUniversity of Stirling; McMaster University
- Sophie Louise WardleUniversity of Stirling
- Lindsay S. MacnaughtonUniversity of Stirling
- Oliver C. WitardUniversity of Stirling
- Fraser ScottUniversity of Stirling
- James DickUniversity of Stirling
Abstract
Fish oil (FO) supplementation potentiates muscle protein synthesis (MPS) in response to a hyperaminoacidemic-hyperinsulinemic infusion. Whether FO supplementation potentiates MPS in response to protein ingestion or when protein ingestion is combined with resistance exercise (RE) remains unknown. In a randomized, parallel group design, 20 healthy males were randomized to receive 5 g/day of either FO or coconut oil control (CO) for 8 weeks. After supplementation, participants performed a bout of unilateral RE followed by ingestion of 30 g of whey protein. Skeletal muscle biopsies were obtained before and after supplementation for assessment of muscle lipid composition and relevant protein kinase activities. Infusion of L-[ring-(13)C6] phenylalanine was used to measure basal myofibrillar MP Sat rest (REST), in a nonexercised leg following protein ingestion (FED) and following RE and protein ingestion (FEDEX).MPS was significantly elevated above REST during FEDEX in both the FO and CO groups, but there was no effect of supplementation. There was a significant increase in MPS in both groups above REST during FED but no effect of supplementation. Supplementation significantly decreased pan PKB activity at RESTin the FO group but not the CO group. There was a significant increase from REST at post-RE for PKB and AMPKα2 activity in the CO group but not in the FO group. In FEDEX, there was a significant increase in p70S6K1 activity from REST at 3 h in the CO group only. These data highlight that 8 weeks of FO supplementation alters kinase signaling activity in response to RE plus protein ingestion without influencing MPS.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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