Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man
Petrović J, Stanić D, Dmitrašinović G, Plećaš-Solarović B, Ignjatović S, Batinić B, Popović D, Pešić V
Oxidative medicine and cellular longevity · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Grants
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (175036)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-01-01 · Oxid Med Cell Longev · vol. 2016 · issue 1 · p. 2019643
- Publisher
- Hindawi Publishing Corporation
- Cited
- 44 citations · more than 98% of similar papers · 9.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 50 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Childhood Cancer Survivors' Quality of Life · Effects of Radiation Exposure · Therapeutic Uses of Natural Elements
- Keywords
- Athletes, Lymphocyte, Peripheral blood, Peripheral blood lymphocyte, Oxidative phosphorylation, Oxidative damage, Immunology, Peripheral, Medicine, Physiology, DNA damage, Oxidative stress, DNA, Endocrinology, Biology, Internal medicine, Physical therapy, Genetics, Biochemistry
- MeSH
- lymphocytes, humans, dna damage, hydrogen peroxide, magnesium, oxidative stress, football, dietary supplements, adult, male, young adult, athletes, sedentary behavior
8 authors
From RS
- Jelena PetrovićUniversity of Belgrade
- Dušanka StanićUniversity of Belgrade
- Gordana DmitrašinovićUniversity of Belgrade
- Bosiljka Plećaš‐SolarovićUniversity of Belgrade
- Svetlana IgnjatovićUniversity of Belgrade
- Bojan BatinićUniversity of Belgrade
Abstract
Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle. Clinical trial is registered at ANZCTR Trial Id: ACTRN12615001237572.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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