Funded in part by Bio-Tech Pharmacal
Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study
McDonnell SL, Baggerly C, French CB, Baggerly LL, Garland CF, Gorham ED, Lappe JM, Heaney RP
PloS one · 86 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Health and Human Services
- Company
- Bio-Tech Pharmacal
- Government
- National Institute on Aging
- Government
- NIA NIH HHS
- Grants
- National Institute on Aging (R01 AG014683); National Institute on Aging (AG14683-01A2)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-04-06 · PLoS One · vol. 11 · issue 4 · p. e0152441
- Publisher
- Public Library of Science
- Cited
- 111 citations · more than 99% of similar papers · 13.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Thyroid Cancer Diagnosis and Treatment · Biotin and Related Studies
- Keywords
- Medicine, Cohort, Prospective cohort study, Internal medicine, Cancer, Incidence (geometry), Cohort study, Proportional hazards model, Gastroenterology
- MeSH
- humans, neoplasms, vitamin d, incidence, risk factors, prospective studies, aged, middle aged, female
8 authors
From US
- Sharon L. McDonnell · correspondingGrassrootsHealth
- Carole A. BaggerlyGrassrootsHealth
- Christine FrenchGrassrootsHealth
- Leo L. BaggerlyGrassrootsHealth
- Cedric F. GarlandUniversity of California San Diego
- Edward Doerr GorhamUniversity of California San Diego
Abstract
Background
Higher serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with a lower risk of multiple cancer types across a range of 25(OH)D concentrations.
Objectives
To investigate whether the previously reported inverse association between 25(OH)D and cancer risk could be replicated, and if a 25(OH)D response region could be identified among women aged 55 years and older across a broad range of 25(OH)D concentrations.
Methods
Data from two cohorts representing different median 25(OH)D concentrations were pooled to afford a broader range of 25(OH)D concentrations than either cohort alone: the Lappe cohort (N = 1,169), a randomized clinical trial cohort (median 25(OH)D = 30 ng/ml) and the GrassrootsHealth cohort (N = 1,135), a prospective cohort (median 25(OH)D = 48 ng/ml). Cancer incidence over a multi-year period (median: 3.9 years) was compared according to 25(OH)D concentration. Kaplan-Meier plots were developed and the association between 25(OH)D and cancer risk was examined with multivariate Cox regression using multiple 25(OH)D measurements and spline functions. The study included all invasive cancers excluding skin cancer.
Results
Age-adjusted cancer incidence across the combined cohort (N = 2,304) was 840 cases per 100,000 person-years (1,020 per 100,000 person-years in the Lappe cohort and 722 per 100,000 person-years in the GrassrootsHealth cohort). Incidence was lower at higher concentrations of 25(OH)D. Women with 25(OH)D concentrations ≥40 ng/ml had a 67% lower risk of cancer than women with concentrations <20 ng/ml (HR = 0.33, 95% CI = 0.12-0.90).
Conclusions
25(OH)D concentrations ≥40 ng/ml were associated with substantial reduction in risk of all invasive cancers combined.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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