Photobiomodulation of Dental Derived Mesenchymal Stem Cells: A Systematic Review
Marques MM, Diniz IM, de Cara SP, Pedroni AC, Abe GL, D'Almeida-Couto RS, Lima PL, Tedesco TK, Moreira MS
Photomedicine and laser surgery · 65 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Based on 1 listed funder(s).
Publication
- Published
- 2016-04-08 · Photomed Laser Surg · vol. 34 · issue 11 · pp. 500–508
- Publisher
- Mary Ann Liebert, Inc.
- Cited
- 109 citations · more than 85% of similar papers · 2.0× the field average
- References
- 40 works
- Access
- Paywalled
- Research areas
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Oral health in cancer treatment
- Keywords
- Systematic review, Medicine, MEDLINE, Web of science, Mesenchymal stem cell, Scopus, Stem cell, Meta-analysis, Pathology, Biology
- MeSH
- dental pulp, humans, mesenchymal stem cell transplantation, sensitivity and specificity, regeneration, cell proliferation, female, male, low-level light therapy
9 authors
From BR
- Márcia Martins Marques · correspondingUniversidade de São Paulo
- Ivana Márcia Alves DinizUniversidade de São Paulo
- Sueli Patricia Harumi Miyagi de CaraCentro Universitário das Faculdades Metropolitanas Unidas
- Ana Clara Fagundes PedroniUniversidade de São Paulo
- Gabriela L. AbeUniversidade de São Paulo
- Roberta Souza D’Almeida CoutoUniversidade Federal do Pará
Abstract
Objective
This study aimed to conduct a systematic review of the literature published from 2000 to August 2015, to investigate the effect of photobiomodulation (PBM) therapy on dentoalveolar-derived mesenchymal stem cells (ddMSCs), assessing whether a clear conclusion can be reached from the data presented.
Background data
Systematic reviews provide the best evidence on the effectiveness of a procedure and permit investigation of factors that may influence the performance of a method. To the best of our knowledge, no previous systematic review has evaluated the effects of PBM only on ddMSCs.
Methods
The search was conducted in PubMed /MEDLINE®, Scopus and Web of Science databases, and reported according to the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA Statement). Original research articles investigating the effects of PBM therapy on ddMSCs, published from 2000 to August 2015, were retrieved and used for this review according to the following eligibility criteria: evaluating PBM therapy, assessing stem cells of dentoalveolar origin, published in English, dealing with cells characterized as stem cells, and using light that did not need external chromophores.
Results
From the initial 3467 potentially relevant articles identified, 6 were excluded because they were duplicates, and 3453 were considered ineligible based on the inclusion criteria. Therefore, eight articles remained, and these were fully analyzed in order to closely check exclusion criteria items. Only one of them was excluded because the cultured cells studied were not characterized as stem cells. Finally, seven articles served as the basis for this systematic review.
Conclusions
PBM therapy has no deleterious effects on ddMSCs. Although no other clear conclusion was obtained because of the scarce number of publications, the results of these studies are pointing to an important tendency of PBM therapy to improve ddMSCs' viability and proliferation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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