Effect of Photobiomodulation on Mesenchymal Stem Cells
Fekrazad R, Asefi S, Allahdadi M, Kalhori KA
Photomedicine and laser surgery · 76 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-04-12 · Photomed Laser Surg · vol. 34 · issue 11 · pp. 533–542
- Publisher
- Mary Ann Liebert, Inc.
- Cited
- 102 citations · more than 98% of similar papers · 9.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 76 works
- Access
- Paywalled
- Research areas
- Laser Applications in Dentistry and Medicine · Planarian Biology and Electrostimulation · Dermatologic Treatments and Research
- Keywords
- Mesenchymal stem cell, Stem cell, Light therapy, Inclusion and exclusion criteria, Medicine, Regeneration (biology), English language, Stem-cell therapy, Light energy, Laser therapy, Laser, Laser light, Low level laser therapy, Cancer research, Pathology, Internal medicine, Biology, Optics, Cell biology, Physics, Psychology
- MeSH
- cells, cultured, mesenchymal stem cells, animals, dogs, humans, mice, radiation dosage, wound healing, cell proliferation, lasers, semiconductor, low-level light therapy
4 authors
From IR, BE
- Reza Fekrazad · correspondingAja University of Medical Sciences
- Sohrab AsefiShahid Beheshti University of Medical Sciences
- Mahdi AllahdadiIS practice
- Katayoun AM KalhoriIranian Orthopedic Association
Abstract
Objective
The purpose of this study was to review available literature about the effect of photobiomodulation (PBM) on mesenchymal stem cells (MSCs).
Background data
The effects of coherent and noncoherent light sources such as low-level lasers and light-emitting diodes (LEDs) on cells and tissues, known as PBM, form the basis of photomedicine. This treatment technique effects cell function, proliferation, and migration, and plays an important role in tissue regeneration. Stem cells have been found to be helpful elements in tissue regeneration, and the combination of stem cell therapy and laser therapy appears to positively affect treatment results.
Materials and methods
An electronic search in PubMed was conducted of publications from the previous 12 years. English language articles related to the subject were found using selected key words. The full texts of potentially suitable articles were assessed according to inclusion and exclusion criteria.
Results
After evaluation, 30 articles were deemed relevant according to the inclusion criteria. The energy density of the laser was 0.7-9 J/cm2. The power used for visible light was 30-110 mW and that used for infrared light was 50-800 mW. Nearly all studies showed that low-level laser therapy had a positive effect on cell proliferation. Similar outcomes were found for LED; however, some studies suggest that the laser alone is not effective, and should be used as an adjunct tool.
Conclusions
PBM has positive effects on MSCs. This review concluded that doses of 0.7-4 J/cm2 and wavelengths of 600-700 nm are appropriate for light therapy. The results were dependent upon different parameters; therefore, optimization of parameters used in light therapy to obtain favorable results is required to provide more accurate comparison.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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