Analysis of 25-Hydroxyvitamin D Status According to Age, Gender, and Seasonal Variation
Yu HJ, Kwon MJ, Woo HY, Park H
Journal of clinical laboratory analysis · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-04-13 · J Clin Lab Anal · vol. 30 · issue 6 · pp. 905–911
- Publisher
- Wiley
- Cited
- 45 citations · more than 91% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Biotin and Related Studies · Thyroid Disorders and Treatments
- Keywords
- Vitamin D and neurology, Medicine, Demography, Internal medicine, Population, Endocrinology
- MeSH
- humans, vitamin d, analysis of variance, retrospective studies, longitudinal studies, seasons, aging, sex characteristics, adolescent, adult, aged, aged, 80 and over, middle aged, female, male, young adult, republic of korea
4 authors
From KR
- Hui‐Jin YuKangbuk Samsung Hospital; Sungkyunkwan University
- Min‐Jung KwonKangbuk Samsung Hospital; Sungkyunkwan University
- Hee‐Yeon WooKangbuk Samsung Hospital; Sungkyunkwan University
- Hyosoon ParkKangbuk Samsung Hospital; Sungkyunkwan University
Abstract
Background
The effects of age, gender, and seasonal variation on human levels of 25-hydroxyvitamin D (25(OH)D) are not well understood. In this study, we aimed to investigate 25(OH)D status according to these factors in a Korean population.
Methods
A total of 303,943 serum 25(OH)D levels were measured using an electrochemiluminescence immunoassay between October 2011 and May 2014. Potential participants were ineligible for the study if they had significant renal, hepatic, or thyroid dysfunction, as well as any major ongoing disease that could influence serum 25(OH)D levels.
Results
A total of 95,137 subjects (49,662 men and 45,475 women) were included in this study. The mean 25(OH)D levels were higher in men (42.4 nmol/l) than in women (32.9 nmol/l, P 75 nmol/l. The highest mean 25(OH)D value was noted in individuals aged ≥70 for both genders. The proportion of those with 25(OH)D levels <50 nmol/l appeared to be higher among younger subjects (P < 0.001). Lastly, there were significant differences between 25(OH)D levels in individuals during summer to fall and winter to spring in both genders, indicating seasonal periodicity (P < 0.001).
Conclusions
Serum 25(OH)D status varied according to gender, age, and season. Therefore, analyses of vitamin D status require individualized gender, age, and seasonally adjusted thresholds. Clinicians should consider these factors when determining optimal serum 25(OH)D levels in clinical practice.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.