Funded in part by Nippon Suisan Kaisya, Ltd.
Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint range of motion after eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial
Tsuchiya Y, Yanagimoto K, Nakazato K, Hayamizu K, Ochi E
European journal of applied physiology · 63 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Nippon Suisan Kaisya, Ltd.
Based on 1 listed funder(s).
Publication
- Published
- 2016-04-16 · Eur J Appl Physiol · vol. 116 · issue 6 · pp. 1179–1188
- Publisher
- Springer Science+Business Media
- Cited
- 92 citations · more than 97% of similar papers · 6.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Fatty Acid Research and Health · Tendon Structure and Treatment
- Keywords
- Docosahexaenoic acid, Fish oil, Eicosapentaenoic acid, Range of motion, Randomized controlled trial, Medicine, Placebo, Eccentric, Double blind, Physical therapy, Sports medicine, Fish <Actinopterygii>, Anesthesia, Internal medicine, Physical medicine and rehabilitation, Polyunsaturated fatty acid, Chemistry, Biology, Biochemistry, Fishery, Physics, Pathology, Fatty acid
- MeSH
- humans, muscle weakness, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, drug combinations, range of motion, articular, treatment outcome, double-blind method, placebo effect, dietary supplements, adult, male, muscle strength, resistance training, myalgia
5 authors
From JP
- Yosuke TsuchiyaMeiji Gakuin University
- Kenichi YanagimotoNippon Suisan Kaisha (Japan)
- Koichi NakazatoNippon Sport Science University
- Kohsuke HayamizuYokohama University of Pharmacy
- Eisuke Ochi · correspondingHosei University
Abstract
Purpose
This study investigated the effect of eicosapentaenoic and docosahexaenoic acids-rich fish oil (EPA + DHA) supplementation on eccentric contraction-induced muscle damage.
Methods
Twenty-four healthy men were randomly assigned to consume the EPA + DHA supplement (EPA, n = 12) or placebo (PL, n = 12) by the double-blind method. Participants consumed EPA + DHA or placebo supplement for 8 weeks prior to exercise and continued it until 5 days after exercise. The EPA group consumed EPA + DHA-rich fish oil containing 600 mg EPA and 260 mg DHA per day. Subjects performed five sets of six maximal eccentric elbow flexion exercises. Changes in the maximal voluntary contraction (MVC) torque, range of motion (ROM), upper arm circumference, muscle soreness as well as serum creatine kinase, myoglobin, IL-6, and TNF-α levels in blood were assessed before, immediately after, and 1, 2, 3, and 5 days after exercise.
Results
MVC was significantly higher in the EPA group than in the PL group at 2-5 days after exercise (p < 0.05). ROM was also significantly greater in the EPA group than in the PL group at 1-5 days after exercise (p < 0.05). At only 3 days after exercise, muscle soreness of the brachialis was significantly greater in the PL group than in the EPA group (p < 0.05), with a concomitant increase in serum IL-6 levels in the PL group.
Conclusion
Eight-week EPA + DHA supplementation attenuates strength loss and limited ROM after exercise. The supplementation also attenuates muscle soreness and elevates cytokine level, but the effect is limited.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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