Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk
Shrestha S, Lutsey PL, Alonso A, Huang X, Mosley TH, Chen H
Movement disorders : official journal of the Movement Disorder Society · 41 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- National Institute of Environmental Health Sciences
- Government
- NHLBI NIH HHS
- Government
- NIH National Heart, Lung, and Blood Institute
- Government
- Intramural NIH HHS
- Government
- Intramural Research Program of the National Institute of Health
- Government
- NINDS NIH HHS
- Government
- NIEHS NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (HHSN268201 100012C); National Heart, Lung, and Blood Institute (HHSN268201100007I); National Heart, Lung, and Blood Institute (R01 HL103706); National Heart, Lung, and Blood Institute (HHSN268201100007C); National Heart, Lung, and Blood Institute (HHSN2682 01100008C); National Heart, Lung, and Blood Institute (HH-SN-268201100006C); National Heart, Lung, and Blood Institute (HHSN268201100011C); National Heart, Lung, and Blood Institute (HHSN2682011-00005I); National Institute of Environmental Health Sciences (Z01-ES 101986); National Heart, Lung, and Blood Institute (HHSN2682011-00009I); National Heart, Lung, and Blood Institute (HHSN268201100005C); National Heart, Lung, and Blood Institute (HHSN268201100005G); National Heart, Lung, and Blood Institute (HHSN268201100010C); National Heart, Lung, and Blood Institute (HHSN268201100011I); National Institute of Neurological Disorders and Stroke (R01‐NS060722); National Heart, Lung, and Blood Institute (HHSN26820 1100009C); National Heart, Lung, and Blood Institute (HHSN2682011-00008I); National Institute of Environmental Health Sciences (R01-ES019672); National Institute of Neurological Disorders and Stroke (U01NS082151); National Institutes of Health (Z01-ES101986)
Based on 10 listed funder(s).
Publication
- Published
- 2016-04-19 · Mov Disord · vol. 31 · issue 7 · pp. 972–978
- Publisher
- Wiley
- Cited
- 63 citations · more than 96% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Parkinson's Disease Mechanisms and Treatments · Folate and B Vitamins Research
- Keywords
- Vitamin D and neurology, Confidence interval, Hazard ratio, Medicine, Internal medicine, Prospective cohort study, Proportional hazards model, Gastroenterology, vitamin D deficiency, Cohort study, Cohort
- MeSH
- humans, parkinson disease, vitamin d, aftercare, risk, aged, middle aged, female, male
6 authors
From US
- Srishti ShresthaNational Institute of Environmental Health Sciences
- Pamela L. LutseyUniversity of Minnesota
- Álvaro AlonsoUniversity of Minnesota
- Xuemei HuangPenn State Milton S. Hershey Medical Center
- Thomas H. MosleyUniversity of Mississippi Medical Center
- Honglei Chen · correspondingNational Institute of Environmental Health Sciences
Abstract
Background
Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.
Methods
Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared with participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval, 0.58-1.90) for 20-30 ng/mL and 1.14 (95% confidence interval, 0.59- 2.23) for ≥30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up.
Conclusion
This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD. © 2016 International Parkinson and Movement Disorder Society.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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