Effect of cholecalciferol supplementation on arterial stiffness: a systematic review and meta-analysis
Upala S, Sanguankeo A, Congrete S, Jaruvongvanich V
Scandinavian cardiovascular journal : SCJ · 22 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-04-22 · Scand Cardiovasc J · vol. 50 · issue 4 · pp. 230–235
- Publisher
- Taylor & Francis
- Cited
- 28 citations · more than 78% of similar papers · 1.2× the field average
- References
- 29 works
- Access
- Free to read
- Research areas
- Cardiovascular Health and Disease Prevention · Vitamin D Research Studies · Sodium Intake and Health
- Keywords
- Medicine, Arterial stiffness, Cholecalciferol, Vitamin D and neurology, Pulse wave velocity, Placebo, Meta-analysis, Internal medicine, Randomized controlled trial, vitamin D deficiency, Surgery, Blood pressure, Pathology
- MeSH
- humans, cardiovascular diseases, cholecalciferol, vitamins, treatment outcome, vascular stiffness, pulse wave analysis
4 authors
From TH, US
- Sikarin UpalaSiriraj Hospital; Mahidol University; Bassett Medical Center; Columbia University
- Anawin Sanguankeo · correspondingSiriraj Hospital; Mahidol University; Bassett Medical Center; Columbia University
- Soontharee CongreteSt. Elizabeth's Medical Center
- Veeravich JaruvongvanichUniversity of Hawaii System
Abstract
Background
Vitamin D deficiency increases risk of cardiovascular diseases, arterial stiffness, and endothelial dysfunction. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the impact of vitamin D supplementation on arterial stiffness.
Methods
A comprehensive search of the databases of the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE was performed from inception through November 2015. The inclusion criterion was RCTs that assessed the impact of cholecalciferol supplementation in adults on the surrogate markers of arterial stiffness (aortic pulse wave velocity (PWV) and augmentation index (AIx)). Outcome was the pooled mean difference (MD) of PWV and AIx between the vitamin D supplementation (intervention) group and placebo.
Results
The initial search yielded 1164 articles. Twenty-eight articles underwent full-length review and data were extracted from seven RCTs involving totally 547 participants. Dose of cholecalciferol supplementation varied from 1000 IU/day to 120,000 IU/month of cholecalciferol. Duration of treatment ranged from 2 to 12 months. There was no significant difference in the change of PWV (pooled MD = 0.18, 95% CI: -0.17 to 0.52 or AIx (pooled MD = 2.39, 95% CI: -4.43 to 4.92) between the intervention group and placebo.
Conclusions
There was no improvement of markers of arterial stiffness after vitamin D supplementation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.