Raised serum 25-hydroxyvitamin D levels in patients with active diabetic foot ulcers
Afarideh M, Ghanbari P, Noshad S, Ghajar A, Nakhjavani M, Esteghamati A
The British journal of nutrition · 36 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-04-08 · Br J Nutr · vol. 115 · issue 11 · pp. 1938–1946
- Publisher
- Cambridge University Press
- Cited
- 59 citations · more than 88% of similar papers · 2.3× the field average
- References
- 37 works
- Access
- Free to read
- Research areas
- Diabetic Foot Ulcer Assessment and Management · Adipokines, Inflammation, and Metabolic Diseases · Exercise and Physiological Responses
- Keywords
- Medicine, Diabetes mellitus, Internal medicine, Diabetic foot, Type 2 diabetes, Gastroenterology, Logistic regression, Pathogenesis, Diabetic foot ulcer, Vitamin D and neurology, Endocrinology
- MeSH
- humans, diabetic foot, diabetes mellitus, type 2, vitamin d deficiency, inflammation, vitamin d, c-reactive protein, cytokines, logistic models, case-control studies, cross-sectional studies, adult, aged, middle aged, female, male, chemokine ccl2
6 authors
From IR
- Mohsen AfaridehTehran University of Medical Sciences
- Parvaneh GhanbariTehran University of Medical Sciences
- Sina NoshadTehran University of Medical Sciences
- Alireza GhajarTehran University of Medical Sciences
- Manouchehr NakhjavaniTehran University of Medical Sciences
- Alireza Esteghamati · correspondingTehran University of Medical Sciences
Abstract
Studies have emerged to demonstrate bidirectional changes in circulating cytokines of inflammation in active diabetic foot ulcers (DFU). To further expand the understanding of inflammatory status present in chronic active DFU, we comparatively assessed the associations of selected pro-inflammatory cytokines and 25-hydroxyvitamin D (25(OH)D) with the presence of DFU. In a cross-sectional setting, thirty patients with type 2 diabetes and active DFU matched with thirty control non-ulcerative patients with type 2 diabetes and twenty-eight healthy subjects underwent anthropometric and biochemical assessment of study parameters. Recruited patients with DFU were selected from the grade II active chronic DFU at the time of hospitalisation according to the University of Texas wound classification system. Patients with DFU and controls had comparable age, sexual distribution, diastolic blood pressure and TAG, LDL-cholesterol and glycated Hb. The trend changes from healthy controls towards DFU showed a significant increase for serum monocyte chemoattractant protein-1, IL-6, 25(OH)D and highly sensitive C-reactive protein and a decrease for IL-8. In the multivariate adjusted logistic regression model, 25(OH)D emerged as the only independent correlate of DFU (OR 2·194; 95 % CI 1·003, 4·415). Unprecedented increase of serum 25(OH)D in chronic active DFU is possibly related to a selective alteration in the inflammatory status. In particular, 25(OH)D and IL-8 seem to share a common pathway in the pathogenesis of diabetic foot.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.