Funded in part by Novo Nordisk Fonden
A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
Romu T, Vavruch C, Dahlqvist-Leinhard O, Tallberg J, Dahlström N, Persson A, Heglind M, Lidell ME, Enerbäck S, Borga M, Nystrom FH
Metabolism: clinical and experimental · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Linköpings Universitet
- Government
- Vetenskapsrådet
- Company
- Novo Nordisk Fonden
- Grants
- Novo Nordisk Fonden (NNF14OC0010547)
Based on 3 listed funder(s).
Publication
- Published
- 2016-04-03 · Metabolism · vol. 65 · issue 6 · pp. 926–934
- Publisher
- Elsevier BV
- Cited
- 40 citations · more than 94% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Keywords
- Brown adipose tissue, Medicine, Animal science, Randomized controlled trial, Magnetic resonance imaging, Nuclear medicine, Ingestion, Adipose tissue, Surgery, Internal medicine, Biology, Radiology
- MeSH
- humans, magnetic resonance imaging, organ size, calorimetry, indirect, energy metabolism, thermogenesis, adult, female, male, adipose tissue, brown, cold temperature, young adult
11 authors
From SE
- Thobias RomuLinköping University
- Camilla VavruchLinköping University
- Olof Dahlqvist-LeinhardLinköping University
- Joakim TallbergLinköping University
- Nils DahlströmLinköping University
- Anders PerssonLinköping University
Abstract
Objective
To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze.
Design
Randomized, open, parallel-group trial.
Methods
Healthy non-selected participants were randomized to achieve cold-exposure 1hour/day, or to avoid any sense of feeling cold, for 6weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI).
Results
Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841±199 kCal/24h to 1795±213 kCal/24h, p=0.047 cold-activated MR from 1900±150 kCal/24h to 1793±215 kCal/24h, p=0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p=0.052). The difference between MR changes by the interventions between groups was statistically significant (p=0.008 at room temperature, p=0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥8days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175±0.015l to 0.0216±0.014l, p=0.049).
Conclusions
We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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