A dietary cholesterol challenge study to assess Chlorella supplementation in maintaining healthy lipid levels in adults: a double-blinded, randomized, placebo-controlled study
Kim S, Kim J, Lim Y, Kim YJ, Kim JY, Kwon O
Nutrition journal · 13 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Science, ICT and Future Planning
- Grants
- Ministry of Science, ICT and Future Planning (2012M3A9C4048761)
Based on 1 listed funder(s).
Publication
- Published
- 2015-12-01 · Nutr J · vol. 15 · issue 1 · p. 54
- Publisher
- BioMed Central
- Cited
- 33 citations · more than 63% of similar papers · 0.4× the field average
- References
- 24 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Algal biology and biofuel production · Seaweed-derived Bioactive Compounds · Biocrusts and Microbial Ecology
- Keywords
- Placebo, Cholesterol, Medicine, Chlorella, Clinical nutrition, Internal medicine, Randomized controlled trial, Endocrinology, Biology, Botany, Pathology, Algae
- MeSH
- humans, chlorella, hypercholesterolemia, carotenoids, lipids, cholesterol, dietary, triglycerides, body mass index, treatment outcome, diet, double-blind method, female, male, cholesterol, ldl, cholesterol, hdl, young adult
6 authors
From KR
- Sangmi KimEwha Womans University
- Joohee KimSeoul National University of Science and Technology; Ewha Womans University
- Yeni LimEwha Womans University
- You Jin KimEwha Womans University
- Ji Yeon KimSeoul National University of Science and Technology; Ewha Womans University
- Oran Kwon · correspondingEwha Womans University
Abstract
Background
Previous animal studies suggested that Chlorella, a unicellular green alga, has a preventive role in maintaining serum cholesterol levels against excess dietary cholesterol intake. This study aimed to conduct a pioneering investigation to clarify this issue in healthy subjects by adopting a dietary cholesterol challenge, which has not been used previously in similar studies of Chlorella in hypercholesterolemia.
Methods
In this double blind, randomized, placebo-controlled study, 34 participants ingested 510 mg of dietary cholesterol from three eggs concomitantly with a usual dose of Chlorella (5 g/d) or a matched placebo for 4 weeks.
Results
The dietary cholesterol challenge induced consistently higher concentrations of serum total cholesterol (TC, P 0.5; Q(2) > 0.4).
Conclusion
The results suggest that a fully replicated dietary cholesterol challenge may be useful in assessing the effectiveness of dietary supplements in maintaining the serum lipid profiles of adults whose habitual diets are high in cholesterol.
Trial registration
WHO International Clinical Trials Registry Platform ( KCT0000258 ).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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