Whole-grain consumption and the risk of all-cause, CVD and cancer mortality: a meta-analysis of prospective cohort studies
Wei H, Gao Z, Liang R, Li Z, Hao H, Liu X
The British journal of nutrition · 35 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-05-24 · Br J Nutr · vol. 116 · issue 3 · pp. 514–525
- Publisher
- Cambridge University Press
- Cited
- 57 citations · more than 77% of similar papers · 1.4× the field average
- References
- 56 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Nutrition and Health in Aging · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Meta-analysis, Whole grains, Prospective cohort study, Relative risk, Cohort study, Cancer, Internal medicine, Confidence interval, Environmental health, Food science
- MeSH
- humans, neoplasms, cardiovascular diseases, diet, feeding behavior, energy intake, aged, middle aged, female, male, whole grains
6 authors
From CN
- Honglei WeiSouthwest Jiaotong University
- Zong GaoShandong University of Traditional Chinese Medicine
- Rui LiangSouthwest Jiaotong University
- Zengqiang LiSouthwest Jiaotong University
- Hong HaoSouthwest Jiaotong University
- Xu Liu · correspondingSouthwest Jiaotong University
Abstract
Results of the relationships between dietary whole-grain consumption and the risk of all-cause, CVD and cancer-specific mortality are mixed. We summarised the evidence based on a meta-analysis of prospective cohort studies. Pertinent studies were identified by searching articles in the MEDLINE and EMBASE databases up to 20 January 2016 and by reviewing the reference lists of the retrieved articles. Random-effects models were used to calculate summary relative risks (SRR) and 95 % CI. In all, eleven prospective studies (ten publications) were included in the meta-analysis. There were a total of 816 599 subjects and 89 251 cases of all-cause mortality. On the basis of the highest v. the lowest categories of intake, whole grains may be associated with a lower risk of mortality from all causes (SRR 0·87; 95 % CI 0·84, 0·90), CVD (SRR 0·81; 95 % CI 0·75, 0·89) and all cancers (SRR 0·89; 95 % CI 0·82, 0·96). For each 3 servings/d increase in whole-grain intake, there was a 19 % reduction in the risk of all-cause mortality (SRR 0·81; 95 % CI 0·76, 0·85), a 26 % reduction in CVD mortality (SRR 0·74; 95 % CI 0·66, 0·83) and a 9 % reduction in cancer mortality (SRR 0·91; 95 % CI 0·84, 0·98). The current meta-analysis provides some evidence that high intake of whole grains was inversely associated with the risk of all-cause, CVD and cancer-specific mortality. Further well-designed studies, including clinical trials and in different populations, are required to confirm our findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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