Effects of Complementary Creatine Monohydrate and Physical Training on Inflammatory and Endothelial Dysfunction Markers Among Heart Failure Patients
Hemati F, Rahmani A, Asadollahi K, Soleimannejad K, Khalighi Z
Asian journal of sports medicine · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-03-05 · Asian J Sports Med · vol. 7 · issue 1 · p. e28578
- Cited
- 20 citations · more than 89% of similar papers · 2.7× the field average
- References
- 44 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Keywords
- Endothelial dysfunction, Creatine, Medicine, Internal medicine, Endothelial activation, Heart failure, C-reactive protein, Gastroenterology, Creatine Monohydrate, Inflammation, Cytokine, Endocrinology, Pathology, Placebo
5 authors
From IR
- Farajollah HematiMedical University of Ilam; Ilam University
- Asghar RahmaniMedical University of Ilam; Ilam University
- Khairollah Asadollahi · correspondingMedical University of Ilam; Ilam University
- Koroush SoleimannejadMedical University of Ilam; Ilam University
- Zahra KhalighiMedical University of Ilam; Ilam University
Abstract
Background
Previous studies have reported endothelial dysfunction and inflammatory cytokine in heart failure patients (HF).
Objectives
The purpose of this study was to determine the effects of creatine monohydrate and exercise on inflammatory and endothelial dysfunction markers among HF patients.
Patients and methods
One hundred patients were prospectively randomized into two groups: Intervention group which received 5 grams/day creatine monohydrate and exercised for 8 weeks; and control group which did not receive any interventions. Interleukine-6 (IL-6), high sensitivity C reactive protein (hs-CRP), P-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) were measured at the start and end of the study for both groups.
Results
In total, 100 patients including 50 controls and 50 intervention group (54% male, mean EF of 34.2 ± 10.5% and 52% male, mean EF of 35.6 ± 12.7%, respectively) were analyzed. The serum levels of hs-CRP and IL-6 increased at the end of the study in the control group compared to the baseline, (7.5 ± 1.5 mg/L vs. 6.9 ± 1.3 mg/L, P 0.05).
Conclusions
Combination of creatine monohydrate and exercise attenuated inflammation and endothelial dysfunction markers among heart failure patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.