Fatigue related impairments in oculomotor control are prevented by caffeine
Connell CJ, Thompson B, Kuhn G, Claffey MP, Duncan S, Gant N
Scientific reports · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-05-25 · Sci Rep · vol. 6 · issue 1 · p. 26614
- Publisher
- Nature Portfolio
- Cited
- 39 citations · more than 80% of similar papers · 1.6× the field average
- References
- 51 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Antioxidant Activity and Oxidative Stress · Ergonomics and Musculoskeletal Disorders · Coffee research and impacts
- Keywords
- Caffeine, Saccadic masking, Placebo, Saccade, Crossover study, Physical medicine and rehabilitation, Central nervous system, Eye movement, Muscle fatigue, Medicine, Neurotransmission, Motor control, Neuroscience, Psychology, Electromyography, Internal medicine
- MeSH
- humans, fatigue, caffeine, eye movements, exercise, motion perception, synaptic transmission, adult, female, male
6 authors
From NZ, CA, GB, US
- Charlotte J. W. ConnellUniversity of Auckland
- Benjamin S. ThompsonUniversity of Waterloo
- Gustav KuhnGoldsmiths University of London
- Michael P. ClaffeyUniversity of California San Diego
- Shelley J. DuncanUniversity of Auckland
- Nicholas Gant · correspondingUniversity of Auckland
Abstract
Strenuous exercise can result in an inability of the central nervous system to drive skeletal muscle effectively, a phenomenon known as central fatigue. The impact of central fatigue on the oculomotor system is currently unexplored. Fatigue that originates in the central nervous system may be related to perturbations in the synthesis and metabolism of several neurotransmitters. In this study we examine central fatigue in the oculomotor system after prolonged exercise. The involvement of central neurotransmission was explored by administering caffeine during exercise. Within a double-blind, randomized, repeated measures, crossover design, 11 cyclists consumed a placebo or caffeine solution during 180 min of stationary cycling. Saccadic eye movements were measured using infra-red oculography. Exercise decreased saccade velocity by 8% (placebo trial). This effect was reversed by caffeine, whereby velocity was increased by 11% after exercise. A non-oculomotor perceptual task (global motion processing) was unaffected by exercise. The human oculomotor system is impaired by strenuous exercise of the locomotor system. Caffeine exerts a protective effect on oculomotor control, which could be related to up-regulated central neurotransmission. In addition, cortical processes supporting global motion perception appear to be robust to fatigue.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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