Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial
Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, Martin J, Makrides M
Pediatrics · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-05-25 · Pediatrics · vol. 137 · issue 6
- Publisher
- American Academy of Pediatrics
- Cited
- 79 citations · more than 98% of similar papers · 8.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 32 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Neonatal Respiratory Health Research · Pediatric health and respiratory diseases
- Keywords
- Medicine, Fish oil, Docosahexaenoic acid, Wheeze, Eicosapentaenoic acid, Allergy, Randomized controlled trial, Relative risk, Asthma, Pregnancy, Confidence interval, Polyunsaturated fatty acid, Pediatrics, Immunology, Internal medicine, Fatty acid, Fish <Actinopterygii>
- MeSH
- animals, humans, dermatophagoides farinae, prenatal exposure delayed effects, hypersensitivity, docosahexaenoic acids, eicosapentaenoic acid, immunoglobulin e, prenatal care, follow-up studies, pregnancy, dietary supplements, adult, child, female, male
7 authors
From AU
- Karen P BestWomen's & Children's Health Research Institute; South Australian Health and Medical Research Institute
- Thomas SullivanThe University of Adelaide
- Debra Jane PalmerThe University of Western Australia; Women's & Children's Health Research Institute
- Michael Gold
- Declan KennedyWomen's and Children's Hospital
- James A. MartinWomen's and Children's Hospital
Abstract
Background and objective
Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy.
Methods
Six-year follow-up of children (n = 706) with a family history of allergic disease from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial. Women were randomly allocated to receive n-3 LCPUFA-rich fish oil capsules (800 mg/d docosahexaenoic acid DHA and 100mg/d eicosapentaenoic acid) or vegetable oil capsules (without n-3 LCPUFA). Allergic disease symptoms including eczema, wheeze, rhinitis, and rhino-conjunctivitis, were assessed using the International Study of Asthma and Allergies in Childhood questionnaire and sensitization to allergens was measured by skin prick test.
Results
There was no difference in the percentage of children with any IgE-associated allergic disease between the n-3 LCPUFA and control groups (116/367 [31.5%] vs 106/336 [31.5%]; adjusted relative risk, 1.04; 95% confidence interval, 0.82-1.33; P = .73). There was a reduction in the percentage of children sensitized to house dust mite Dermatophagoides farinae (49/367 [13.4%] vs 68/336 [20.3%]; adjusted relative risk, 0.67, 95% confidence interval, 0.44-1.00; P = .0495).
Conclusions
Prenatal n-3 LCPUFA supplementation did not reduce IgE-associated allergic disease at 6 years of age. Secondary outcomes were suggestive of a protective effect of the intervention on the incidence of D. farinae sensitization.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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