Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study
Song M, Konijeti GG, Yuan C, Ananthakrishnan AN, Ogino S, Fuchs CS, Giovannucci EL, Ng K, Chan AT
Cancer prevention research (Philadelphia, Pa.) · 35 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Grants
- National Cancer Institute (P01 CA055075.); National Cancer Institute (K07CA148894); National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (R01CA169141); National Cancer Institute (R35CA197735); National Cancer Institute (R01‐CA049449); National Cancer Institute (R01-CA137178); National Cancer Institute (P50-CA127003); National Institute of Diabetes and Digestive and Kidney Diseases (K24 [DK]098311); National Cancer Institute (R01-CA151993)
Based on 4 listed funder(s).
Publication
- Published
- 2016-05-31 · Cancer Prev Res (Phila) · vol. 9 · issue 8 · pp. 664–672
- Publisher
- American Association for Cancer Research
- Cited
- 45 citations · more than 96% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Intestinal and Peritoneal Adhesions
- Keywords
- Colorectal cancer, Vitamin D and neurology, Medicine, Cancer, Cancer prevention, Vitamin, Internal medicine, Oncology
- MeSH
- humans, colorectal neoplasms, vitamin d, vitamin d-binding protein, odds ratio, risk factors, cohort studies, polymorphism, single nucleotide, adult, aged, middle aged, female, biomarkers, tumor
9 authors
From US
- Mingyang SongHarvard University; Massachusetts General Hospital
- Gauree Gupta KonijetiScripps Research Institute; Scripps Clinic
- Chen YuanHarvard University
- Ashwin N. AnanthakrishnanMassachusetts General Hospital
- Shuji OginoBrigham and Women's Hospital; Harvard University; Dana-Farber Cancer Institute
- Charles S. FuchsBrigham and Women's Hospital; Dana-Farber Cancer Institute
Abstract
Total circulating 25-hydroxyvitamin D [25(OH)D)] has been associated with lower risk of colorectal cancer. The physiologic mechanism, however, may be more directly related to the free or bioavailable fraction of 25(OH)D, which is influenced by levels of vitamin D binding protein (VDBP). We assessed the association of prediagnosis total, free, and bioavailable 25(OH)D and VDBP with colorectal cancer risk among predominantly white women in the Nurses' Health Study (NHS) who provided a blood specimen in 1989-1990. We documented 378 cases of colorectal cancer through 2011 and matched them to 689 controls according to age and time of blood draw. We genotyped two common polymorphisms in the gene coding VDBP and calculated free and bioavailable 25(OH)D levels based on total 25(OH)D, VDBP, albumin, and their estimated genotype-specific binding affinities. Total 25(OH)D was associated with lower colorectal cancer risk (P for trend = 0.01). Compared with women in the lowest quintile of total 25(OH)D, those in the highest quintile had a multivariable-adjusted odds ratio (OR) for colorectal cancer of 0.54 [95% confidence interval (CI), 0.33-0.87]. Comparing extreme quintiles, we did not find any significant association with risk of colorectal cancer for VDBP (OR, 0.98; 95% CI, 0.65-1.47), free 25(OH)D (OR, 0.71; 95% CI, 0.46-1.10), or bioavailable 25(OH)D (OR, 0.92; 95% CI, 0.60-1.42). In conclusion, prediagnosis levels of total, but not free or bioavailable 25(OH)D, were associated with lower colorectal cancer risk. Although our findings support an inverse association of vitamin D with colorectal cancer, this association does not appear to be due to the unbound or bioavailable fraction of circulating vitamin D. Cancer Prev Res; 9(8); 664-72. ©2016 AACR.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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