Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial
Buil-Cosiales P, Toledo E, Salas-Salvadó J, Zazpe I, Farràs M, Basterra-Gortari FJ, Diez-Espino J, Estruch R, Corella D, Ros E, Marti A, Gómez-Gracia E, Ortega-Calvo M, Arós F, Moñino M, Serra-Majem L, Pintó X, Lamuela-Raventós RM, Babio N, Gonzalez JI, Fitó M, Martínez-González MA, PREDIMED investigators
The British journal of nutrition · 51 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Instituto de Salud Carlos III
Based on 1 listed funder(s).
Publication
- Published
- 2016-06-06 · Br J Nutr · vol. 116 · issue 3 · pp. 534–546
- Publisher
- Cambridge University Press
- Cited
- 83 citations · more than 99% of similar papers · 11.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Hazard ratio, Mediterranean diet, Lower risk, Proportional hazards model, Prospective cohort study, Myocardial infarction, Cohort study, Cohort, Food group, Confidence interval, Demography, Internal medicine, Environmental health
- MeSH
- humans, fruit, vegetables, cardiovascular diseases, diet, diet surveys, incidence, proportional hazards models, risk factors, prospective studies, feeding behavior, dietary fiber, aged, aged, 80 and over, middle aged, mediterranean region, female, male, whole grains
23 authors
From ES
- Pilar Buil‐CosialesInstituto de Salud Carlos III; Servicio Navarro de Salud; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red
- Estefanía Toledo · correspondingInstituto de Salud Carlos III; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Jordi Salas‐SalvadóInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Itzíar ZazpeInstituto de Salud Carlos III; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Marta FarràsUniversitat Autònoma de Barcelona; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Hospital Del Mar
- Francisco Javier Basterra-GortariInstituto de Salud Carlos III; Servicio Navarro de Salud; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red
Abstract
Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk. We followed-up 7216 men (55-80 years) and women (60-80 years) initially free of CVD for up to 7 years in the PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The primary end point, confirmed by a blinded ad hoc Event Adjudication Committee, was a composite of cardiovascular death, myocardial infarction and stroke. Time-dependent Cox's regression models were used to estimate the risk of CVD according to baseline dietary exposures and to their yearly updated changes. We found a significant inverse association for fibre (P for trend=0·020) and fruits (P for trend=0·024) in age-sex adjusted models, but the statistical significance was lost in fully adjusted models. However, we found a significant inverse association with CVD incidence for the sum of fruit and vegetable consumption. Participants who consumed in total nine or more servings/d of fruits plus vegetables had a hazard ratio 0·60 (95 % CI 0·40, 0·96) of CVD in comparison with those consuming <5 servings/d.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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