Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells
Fogli S, Arena C, Carpi S, Polini B, Bertini S, Digiacomo M, Gado F, Saba A, Saccomanni G, Breschi MC, Nieri P, Manera C, Macchia M
Nutrition and cancer · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-06-07 · Nutr Cancer · vol. 68 · issue 5 · pp. 873–877
- Publisher
- Routledge
- Cited
- 87 citations · more than 99% of similar papers · 13.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 20 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Essential Oils and Antimicrobial Activity · Edible Oils Quality and Analysis · Phytochemicals and Antioxidant Activities
- Keywords
- Melanoma, In vitro, Olive oil, Chemistry, Pharmacology, Cytotoxicity, Cytotoxic T cell, Biochemistry, Biology, Cancer research, Food science
- MeSH
- cell line, tumor, humans, melanoma, skin neoplasms, aldehydes, phenols, proto-oncogene proteins c-bcl-2, inhibitory concentration 50, cell survival, map kinase signaling system, down-regulation, oncogene protein v-akt, olive oil, cyclopentane monoterpenes, cutaneous malignant melanoma
13 authors
From IT
- Stefano Fogli · correspondingUniversity of Pisa
- Chiara ArenaUniversity of Pisa
- Sara CarpiUniversity of Pisa
- Beatrice PoliniUniversity of Pisa
- Simone BertiniUniversity of Pisa
- Maria DigiacomoUniversity of Pisa
Abstract
Oleocanthal is one of the phenolic compounds of extra virgin olive oil with important anti-inflammatory properties. Although its potential anticancer activity has been reported, only limited evidence has been provided in cutaneous malignant melanoma. The present study is aimed at investigating the selective in vitro antiproliferative activity of oleocanthal against human malignant melanoma cells. Since oleocanthal is not commercially available, it was obtained as a pure standard by direct extraction and purification from extra virgin olive oil. Cell viability experiments carried out by WST-1 assay demonstrated that oleocanthal had a remarkable and selective activity for human melanoma cells versus normal dermal fibroblasts with IC50s in the low micromolar range of concentrations. Such an effect was paralleled by a significant inhibition of ERK1/2 and AKT phosphorylation and downregulation of Bcl-2 expression. These findings may suggest that extra virgin olive oil phenolic extract enriched in oleocanthal deserves further investigation in skin cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.