Effect of the transdermal low-level laser therapy on endothelial function
Szymczyszyn A, Doroszko A, Szahidewicz-Krupska E, Rola P, Gutherc R, Jasiczek J, Mazur G, Derkacz A
Lasers in medical science · 22 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-06-14 · Lasers Med Sci · vol. 31 · issue 7 · pp. 1301–1307
- Publisher
- Springer Science+Business Media
- Cited
- 41 citations · more than 84% of similar papers · 1.8× the field average
- References
- 36 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research
- Keywords
- Angiogenesis, Nitric oxide, Endocrinology, Low level laser therapy, Vascular endothelial growth factor, Angiostatin, Transdermal, Medicine, Endothelial dysfunction, Internal medicine, Asymmetric dimethylarginine, Glutathione, Chemistry, Pharmacology, Arginine, Laser therapy, VEGF receptors, Laser, Biochemistry
- MeSH
- humans, nitric oxide, angiostatins, vascular endothelial growth factor a, fibroblast growth factors, arginine, glutathione, adult, female, male, lasers, semiconductor, low-level light therapy
8 authors
From PL
- Alicja SzymczyszynWroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
- Adrian DoroszkoWroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
- Ewa Szahidewicz-KrupskaWroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
- Piotr RolaWroclaw Research Centre EIT+ (Poland)
- Radosław GuthercWroclaw Research Centre EIT+ (Poland)
- Jakub JasiczekWroclaw Research Centre EIT+ (Poland)
Abstract
The effect of low-level laser therapy (LLLT) on the cardiovascular system is not fully established. Since the endothelium is an important endocrine element, establishing the mechanisms of LLLT action is an important issue.The aim of the study was to evaluate the effect of transdermal LLLT on endothelial function.In this study, healthy volunteers (n = 40, age = 20-40 years) were enrolled. N = 30 (14 female, 16 male, mean age 30 ± 5 years) constituted the laser-irradiated group (LG). The remaining 10 subjects (6 women, 4 men, mean age 28 ± 5 years) constituted the control group (CG). Participants were subjected to LLLT once a day for three consecutive days. Blood for biochemical assessments was drawn before the first irradiation and 24 h after the last session. In the LG, transdermal illumination of radial artery was conducted (a semiconductor laser λ = 808 nm, irradiation 50 mW, energy density 1.6 W/cm(2) and a dose 20 J/day, a total dose of 60 J). Biochemical parameters (reflecting angiogenesis: vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), angiostatin; antioxidative status: glutathione (GSH) and the nitric oxide metabolic pathway: symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA) and L-arginine) were assessed. In the LG, a significant increase in GSH levels and considerable decrease in angiostatin concentration following the LLLT were observed. No significant differences in levels of the VEGF, FGF, SDMA, ADMA were observed.LLLT modifies vascular endothelial function by increasing its antioxidant and angiogenic potential. We found no significant differences in levels of the nitric oxide pathway metabolites within 24 h following the LLLT irradiation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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