Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
Kuda O, Brezinova M, Rombaldova M, Slavikova B, Posta M, Beier P, Janovska P, Veleba J, Kopecky J, Kudova E, Pelikanova T, Kopecky J
Diabetes · 150 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Grantová Agentura České Republiky
- University or hospital
- Akademie Věd České Republiky
- Government
- Ministry of Education, Youth and Sports of the Czech Republic
- Government
- Czech Science Foundation
- Grants
- Grantová Agentura České Republiky (14-3684G)
Based on 4 listed funder(s).
Publication
- Published
- 2016-06-16 · Diabetes · vol. 65 · issue 9 · pp. 2580–2590
- Publisher
- American Diabetes Association
- Cited
- 186 citations · more than 99% of similar papers · 10.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 50 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Eicosanoids and Hypertension Pharmacology · Peroxisome Proliferator-Activated Receptors
- Keywords
- Docosahexaenoic acid, Fatty acid, Polyunsaturated fatty acid, Chemistry, Biochemistry
- MeSH
- cells, cultured, 3t3-l1 cells, adipocytes, animals, mice, inbred c57bl, humans, mice, diabetes mellitus, type 2, insulin resistance, obesity, inflammation, esters, lipopolysaccharides, docosahexaenoic acids, fatty acids, unsaturated, linoleic acid, anti-inflammatory agents, phagocytosis, macrophage activation, male, adipose tissue, white
12 authors
From CZ
- Ondřej KudaCzech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Marie BřezinováCzech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Martina RombaldováCzech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Barbora Slavı́kováCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
- Martin PoštaCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
- Petr BeierCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
Abstract
White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obese individuals, contributes to the development of insulin resistance and type 2 diabetes. n-3 polyunsaturated fatty acids (PUFAs) of marine origin play an important role in the resolution of inflammation and exert beneficial metabolic effects. Using experiments in mice and overweight/obese patients with type 2 diabetes, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids-lipokines derived from docosahexaenoic acid (DHA) and linoleic acid, which were present in serum and WAT after n-3 PUFA supplementation. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) or 14-hydroxydocosahexaenoic acid (HDHA), termed 9-DHAHLA, 13-DHAHLA, and 14-DHAHDHA, and were synthesized by adipocytes at concentrations comparable to those of protectins and resolvins derived from DHA in WAT. 13-DHAHLA exerted anti-inflammatory and proresolving properties while reducing macrophage activation by lipopolysaccharides and enhancing the phagocytosis of zymosan particles. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed to n-3 PUFAs, in both mice and humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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