Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases
Yun EJ, Song KS, Shin S, Kim S, Heo JY, Kweon GR, Wu T, Park JI, Lim K
Oncotarget · 34 citations
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Research Foundation
- University or hospital
- Chungnam National University
- Government
- Ministry of Science, ICT and Future Planning
- Government
- National Research Foundation of Korea
Based on 4 listed funder(s).
Publication
- Published
- 2016-06-23 · Oncotarget · vol. 7 · issue 31 · pp. 49961–49971
- Publisher
- Impact Journals LLC
- Cited
- 47 citations · more than 82% of similar papers · 1.7× the field average
- References
- 54 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Cancer, Lipids, and Metabolism · Inflammatory mediators and NSAID effects · Fatty Acid Research and Health
- Keywords
- Breast cancer, Metastasis, Cancer research, Docosahexaenoic acid, Medicine, Metastatic breast cancer, Matrix metalloproteinase, Cancer, Lung cancer, In vivo, Internal medicine, Oncology, Biology, Fatty acid, Polyunsaturated fatty acid
- MeSH
- cell line, tumor, animals, mice, inbred c57bl, mice, transgenic, humans, mice, breast neoplasms, neoplasm invasiveness, neoplasm metastasis, disease progression, docosahexaenoic acids, dinoprostone, nf-kappa b, culture media, conditioned, apoptosis, cell proliferation, cell movement, cell survival, gene expression regulation, neoplastic, active transport, cell nucleus, female, cyclooxygenase 2, matrix metalloproteinase 2, matrix metalloproteinase 9, matrix metalloproteinase inhibitors
9 authors
From KR, US
- Eun-Jin Yun · correspondingChungnam National University; The University of Texas Southwestern Medical Center
- Kyung-Sub Song · correspondingTulane University; Chungnam National University
- Soyeon ShinChungnam National University
- Soyeon KimChungnam National University
- Jun Young HeoChungnam National University
- Gi‐Ryang KweonChungnam National University
Abstract
Breast cancer is one of the most prevalent cancers in women, and nearly half of breast cancer patients develop distant metastatic disease after therapy. Despite the significant advances that have been achieved in understanding breast cancer metastasis in the past decades, metastatic cancer is still hard to cure. Here, we demonstrated an anti-cancer mechanism of docosahexaenoic acid (DHA) that suppressed lung metastasis in breast cancer. DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE2-NF-κB-MMPs cascades. DHA treatment significantly decreased Cox-2 and NF-κB expression as well as nuclear translocation of NF-κB in MDA-MB-231 cells. In addition, DHA also reduced NF-κB binding to DNA which may lead to inactivation of MMPs. Moreover, in vivo studies using Fat-1 transgenic mice showed remarkable decrease of tumor growth and metastasis to EO771 cells to lung in DHA-rich environment. In conclusion, DHA attenuated breast cancer progression and lung metastasis in part through suppressing MMPs, and these findings suggest chemoprevention and potential therapeutic strategy to overcome malignant breast cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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