Low serum 25-hydroxyvitamin D level and risk of urinary tract infection in infants
Yang J, Chen G, Wang D, Chen M, Xing C, Wang B
Medicine · 17 citations
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Wenzhou Medical University
- University or hospital
- Southern Medical University
Based on 2 listed funder(s).
Publication
- Published
- 2016-07-01 · Medicine (Baltimore) · vol. 95 · issue 27 · p. e4137
- Publisher
- Wolters Kluwer
- Cited
- 36 citations · more than 95% of similar papers · 5.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Pediatric Urology and Nephrology Studies · Vitamin D Research Studies · Birth, Development, and Health
- Keywords
- Medicine, Odds ratio, Vitamin D and neurology, Urinary system, Internal medicine, Gastroenterology, vitamin D deficiency, Logistic regression
- MeSH
- humans, urinary tract infections, vitamin d deficiency, vitamin d, risk factors, infant, female, male
6 authors
From CN
- Jianhuan YangWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University; Zhujiang Hospital; Southern Medical University
- Guangdao ChenPanyu District Central Hospital
- Dexuan WangWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Minguang ChenWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Chao XingWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Bin Wang · correspondingZhujiang Hospital; Southern Medical University
Abstract
The aim of the study is to determine whether serum 25-hydroxyvitamin D (25(OH)D) deficiency in infants increased odds of urinary tract infection (UTI). A total of 238 infants including 132 patients experiencing a first episode of UTI and 106 controls, aged from 1 to 12 months, were enrolled. Serum 25(OH)D levels were tested through blood sampling. The serum 25(OH)D levels were significantly lower in cases with UTI than controls. The mean serum 25(OH)D levels were 29.09 ± 9.56 ng/mL in UTIs and 38.59 ± 12.41 ng/mL in controls (P < 0.001). Infants with acute pyelonephritis (APN) had lower serum 25(OH)D than those with lower UTI. The multivariate logistic regression analyses showed that serum 25(OH)D < 20 ng/mL (OR 5.619, 95% CI 1.469-21.484, P = 0.012) was positively related to an increased odds of UTI. Vitamin D supplementation (OR 0.298, 95% CI 0.150-0.591; P = 0.001) was associated with a decreased likelihood of UTI. Vitamin D deficiency in infants was associated with an increased odds of UTI. Interventional studies evaluating the role of vitamin D supplementation to reduce the burden of UTI are warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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