MDMA Impairs Response to Water Intake in Healthy Volunteers
Baggott MJ, Garrison KJ, Coyle JR, Galloway GP, Barnes AJ, Huestis MA, Mendelson JE
Advances in pharmacological sciences · 4 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- University or hospital
- University of California, San Francisco
- Government
- National Institute on Drug Abuse
- Government
- National Center for Research Resources
- Government
- NIDA NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Center for Research Resources (DA016776); National Institute on Drug Abuse (R01 DA016776); National Center for Research Resources (DA017716); National Center for Research Resources (UCSF-CTSI UL1 RR-024131); National Center for Research Resources (UL1 RR024131); University of California, San Francisco (UL1RR024131); National Institute on Drug Abuse (R01 DA017716); National Institutes of Health (UL1-RR-024131); National Institutes of Health (RR024131); National Institutes of Health (DA016776); National Institutes of Health (DA017716); National Institutes of Health (DA017716 and DA016776); National Institutes of Health (UCSF- CTSI UL1 RR024131)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-01-01 · Adv Pharmacol Sci · vol. 2016 · pp. 1–11
- Publisher
- Hindawi Publishing Corporation
- Cited
- 13 citations · more than 74% of similar papers · 1.2× the field average
- References
- 66 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Forensic Toxicology and Drug Analysis · Psychedelics and Drug Studies · Neurotransmitter Receptor Influence on Behavior
- Keywords
- MDMA, Placebo, Medicine, Hyponatremia, Antidiuretic, Prazosin, Pharmacology, Anesthesia, Internal medicine, Endocrinology, Hormone, Antagonist
7 authors
From US
- Matthew J. Baggott · correspondingFriends Research Institute
- Kathleen J. GarrisonFriends Research Institute
- Jeremy CoyleUniversity of California, Berkeley
- Gantt P. GallowayFriends Research Institute
- Allan J. BarnesNational Institute on Drug Abuse
- Marilyn Ann HuestisNational Institute on Drug Abuse
Abstract
Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In Study 2, volunteers received MDMA or placebo followed by standardized water intake. MDMA lowered serum sodium but did not increase ADH or copeptin, although the control prazosin did increase ADH. Water loading reduced serum sodium more after MDMA than after placebo. There was a trend for women to have lower baseline serum sodium than men, but there were no significant interactions with drug condition. Combining studies, MDMA potentiated the ability of water to lower serum sodium. Thus, hyponatremia appears to be a significant risk when hypotonic fluids are consumed during MDMA use. Clinical trials and events where MDMA use is common should anticipate and mitigate this risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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