The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat
Kasielski M, Eusebio MO, Pietruczuk M, Nowak D
Nutrition journal · 22 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Uniwersytet Łódzki
- University or hospital
- Uniwersytet Medyczny w Lodzi
- Grants
- Uniwersytet Medyczny w Lodzi (503/8-071-03/503-01)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-12-01 · Nutr J · vol. 15 · issue 1 · p. 68
- Publisher
- BioMed Central
- Cited
- 36 citations · more than 84% of similar papers · 1.7× the field average
- References
- 54 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Telomeres, Telomerase, and Senescence · Birth, Development, and Health · Nutritional Studies and Diet
- Keywords
- Telomere, Red meat, Medicine, Peripheral blood mononuclear cell, Clinical nutrition, Food science, Physiology, Internal medicine, Biology, Genetics, Pathology, Gene
- MeSH
- leukocytes, mononuclear, telomere, humans, fruit, vegetables, exercise, diet, prospective studies, cross-sectional studies, smoking, socioeconomic factors, beverages, dairy products, adolescent, adult, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, young adult, surveys and questionnaires, edible grain, red meat
4 authors
From PL
- Marek Kasielski · correspondingMedical University of Lodz
- Makandjou-Ola EusebioMedical University of Lodz
- Mirosława PietruczukMedical University of Lodz
- Dariusz NowakMedical University of Lodz
Abstract
Background
Repeated nucleotide sequences combined with proteins called telomeres cover chromosome ends and dictate cells lifespan. Many factors can modify telomere length, among them are: nutrition and smoking habits, physical activities and socioeconomic status measured by education level. The aim of the study was to determine the influence of above mentioned factors on peripheral blood mononuclear cells telomere length.
Methods
Study included 28 subjects (seven male and 21 female, age 18-65 years.), smokers and non-smokers without any serious health problems in past and present. Following a basic medical examination, patients completed the food frequency questionnaire with 17 foods and beverages most common groups and gave blood for testing. PBMC telomere length were measured with qualitative real-time Polymerase Chain Reaction (rtPCR) method and expressed as a T/S ratio.
Results
Among nine food types (cereal, fruits, vegetables, diary, red meat, poultry, fish, sweets and salty snacks) and eight beverages (juices, coffee, tea, mineral water, alcoholic- and sweetened carbonated beverages) only intake of red meat was related to T/S ratio. Individuals with increased consumption of red meat have had higher T/S ratio and the strongest significant differences were observed between consumer groups: "never" and "1-2 daily" (p = 0.02). Smoking habits, physical activity, LDL and HDL concentrations, and education level were not related to telomere length, directly or as a covariates.
Conclusions
Unexpected correlation of telomere length with the frequency of consumption of red meat indicates the need for further in-depth research and may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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