Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study
Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Le Goff M, Samieri C, Dartigues JF, Delcourt C
PloS one · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Nonprofit
- Fondation Voir et Entendre
- Government
- Caisse nationale de solidarité pour l'autonomie
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-07-28 · PLoS One · vol. 11 · issue 7 · p. e0160240
- Publisher
- Public Library of Science
- Cited
- 42 citations · more than 93% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 69 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Retinal Diseases and Treatments · Glaucoma and retinal disorders · Ophthalmology and Visual Impairment Studies
- Keywords
- Macular degeneration, Medicine, Odds ratio, Olive oil, Confidence interval, Confounding, Logistic regression, Food science, Population, Environmental health, Ophthalmology, Internal medicine, Biology
- MeSH
- humans, macular degeneration, population surveillance, nutritional status, aged, france, female, male, olive oil
9 authors
From FR
- Audrey Cougnard‐Grégoire · correspondingUniversité de Bordeaux; Inserm; Bordeaux Population Health
- Bénédicte M. J. MerleUniversité de Bordeaux; Inserm; Bordeaux Population Health
- Jean‐François KorobelnikUniversité de Bordeaux; Inserm; Centre Hospitalier Universitaire de Bordeaux; Bordeaux Population Health
- Marie‐Bénédicte RougierUniversité de Bordeaux; Inserm; Centre Hospitalier Universitaire de Bordeaux; Bordeaux Population Health
- Marie‐Noëlle DelyferUniversité de Bordeaux; Inserm; Centre Hospitalier Universitaire de Bordeaux; Bordeaux Population Health
- Mélanie Le GoffUniversité de Bordeaux; Inserm; Bordeaux Population Health
Abstract
Background
Olive oil provides a mixture of lipids and antioxidant nutrients which may help preventing age-related diseases such as age-related macular degeneration (AMD). However, little is known about the associations between olive oil consumption and the risk of AMD.
Objective
To examine associations between olive oil use and AMD prevalence in elderly subjects.
Methods
Alienor (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) is a population-based study on eye diseases performed in elderly residents of Bordeaux (France). In 1999-2000, frequencies of consumption of main categories of dietary fats used were collected. In 2006-2088, AMD was graded from non mydriatic retinal photographs into three exclusive stages: no AMD, early AMD, and late AMD. Two categories of preferred dietary fat used (olive oil, n-3 rich oils, n-6 rich oils, mixed oils, butter and margarine) were defined: "no use" and "regular use" (using fat for spreading and/or cooking and/or dressing). Associations of AMD with each fat use were estimated using Generalized Estimating Equation logistic regressions models.
Results
Our study included 654 subjects (1269 eyes) with complete data (n = 268 eyes with early AMD and n = 56 with late AMD). After adjustment for potential confounders, regular use of olive oil was significantly associated with a decreased risk of late AMD (odds ratio [OR] = 0.44, 95% confidence interval [CI]: 0.21;0.91). In contrast, regular use of olive oil was not significantly associated with early AMD (OR = 0.84, 95%CI: 0.59;1.21). No associations were found between regular consumption of n-3 rich oils, n-6 rich oils, mixed oils, butter and margarine and AMD, whatever the stage.
Conclusions
This study suggests a protective effect of olive oil consumption for late AMD in this elderly community-dwelling population. Characterization of the mediating nutrients deserves further research.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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