Association between dietary nitrate and nitrite intake and sitespecific cancer risk: evidence from observational studies
Xie L, Mo M, Jia HX, Liang F, Yuan J, Zhu J
Oncotarget · 59 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-07-29 · Oncotarget · vol. 7 · issue 35 · pp. 56915–56932
- Publisher
- Impact Journals LLC
- Cited
- 85 citations · more than 95% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 89 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Nutritional Studies and Diet · Folate and B Vitamins Research · Sulfur Compounds in Biology
- Keywords
- Observational study, Medicine, Nitrite, Dietary Nitrate, Nitrate, Internal medicine, Environmental health, Oncology, Physiology, Biology, Ecology
- MeSH
- humans, neoplasms, nitrates, nitrites, diet, risk, algorithms, female, male, observational studies as topic
6 authors
From CN
- Li Xie · correspondingShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Miao Mo · correspondingShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Huixun JiaShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Fei LiangShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Jing YuanShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Ji Ye ZhuShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
Abstract
Epidemiological studies have reported inconsistent findings on the association between dietary nitrate and nitrite intake and cancer risk. We performed a meta-analysis of epidemiological studies to summarize available evidence on the association between dietary nitrate and nitrite intake and cancer risk from published prospective and case-control studies. PubMed database was searched to identify eligible publications through April 30th, 2016. Study-specific relative risks (RRs) with corresponding 95% confidence interval (CI) from individual studies were pooled by using random- or fixed- model, and heterogeneity and publication bias analyses were conducted. Data from 62 observational studies, 49 studies for nitrates and 51 studies for nitrites, including a total of 60,627 cancer cases were analyzed. Comparing the highest vs. lowest levels, dietary nitrate intake was inversely associated with gastric cancer risk (RR = 0.78; 95%CI = 0.67-0.91) with moderate heterogeneity (I2 = 42.3%). In contrast, dietary nitrite intake was positively associated with adult glioma and thyroid cancer risk with pooled RR of 1.21 (95%CI = 1.03-1.42) and 1.52 (95%CI = 1.12-2.05), respectively. No significant associations were found between dietary nitrate/nitrite and cancers of the breast, bladder, colorectal, esophagus, renal cell, non-Hodgkin lymphoma, ovarian, and pancreas. The present meta-analysis provided modest evidence that positive associations of dietary nitrate and negative associations of dietary nitrite with certain cancers.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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