Funded in part by Abbott Laboratories
The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans: A Randomized Controlled Trial
Bressendorff I, Brandi L, Schou M, Nygaard B, Frandsen NE, Rasmussen K, Ødum L, Østergaard OV, Hansen D
PloS one · 26 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Abbott Laboratories
- Nonprofit
- Dansk Nefrologisk Selskab
- Government
- Region Sjælland
- Nonprofit
- Region Zealand Health Sciences Research Foundation
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-08-10 · PLoS One · vol. 11 · issue 8 · p. e0160905
- Publisher
- Public Library of Science
- Cited
- 36 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Cardiovascular Health and Disease Prevention · Heart Rate Variability and Autonomic Control
- Keywords
- Arterial stiffness, Cholecalciferol, Blood pressure, Medicine, Peripheral, Randomized controlled trial, Vitamin D and neurology, Peripheral blood, Internal medicine, Cardiology
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamin d, treatment outcome, blood pressure, adult, middle aged, female, male, vascular stiffness
9 authors
From DK
- Iain Oshoj Bressendorff · correspondingZealand University Hospital
- Lisbet BrandiZealand University Hospital
- Morten SchouGentofte Hospital
- Birgitte NygaardRoskilde Sygehus
- Niels Erik FrandsenRoskilde Sygehus
- Knud RasmussenRoskilde Sygehus
Abstract
Background
Low levels of serum 25-hydroxy vitamin D are associated with increased arterial stiffness and hypertension. Supplementation with vitamin D precursors has been proposed as a treatment option for these conditions. We examined the effect of oral cholecalciferol on arterial stiffness and blood pressure in healthy normotensive adults.
Methods
40 healthy adults were randomised in this double-blinded study to either oral cholecalciferol 3000 IU/day or matching placebo and were followed for 16 weeks to examine any effects on pulse wave velocity (PWV), augmentation index (AIx), peripheral and central blood pressure and 24-hour ambulatory blood pressure.
Results
22 subjects in the cholecalciferol arm and 18 subjects in the placebo arm completed the 16 weeks of follow-up. There was no difference in changes in PWV, AIx corrected for heart rate or central or peripheral blood pressure between the two groups. There was no correlation between serum 25-hydroxy vitamin D and any of these parameters.
Conclusions
Oral cholecalciferol 3000 IU/day does not affect arterial stiffness or blood pressure after 16 weeks of treatment in healthy normotensive adults.
Trial registration
ClinicalTrials.gov NCT00952562.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.