Plasma 25-Hydroxyvitamin D and Risk of Breast Cancer in Women Followed over 20 Years
Eliassen AH, Warner ET, Rosner B, Collins LC, Beck AH, Quintana LM, Tamimi RM, Hankinson SE
Cancer research · 38 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (R01-CA49449); National Cancer Institute (R01‐CA049449); National Cancer Institute (P01 CA87969 and UM1 CA186107); National Cancer Institute (U01 CA049449)
Based on 3 listed funder(s).
Publication
- Published
- 2016-08-17 · Cancer Res · vol. 76 · issue 18 · pp. 5423–5430
- Publisher
- American Association for Cancer Research
- Cited
- 45 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Cancer Risks and Factors
- Keywords
- Calcitriol receptor, Vitamin D and neurology, Medicine, Breast cancer, Internal medicine, Relative risk, Confidence interval, Gastroenterology, Tissue microarray, Endocrinology, Cancer, Oncology
- MeSH
- humans, breast neoplasms, vitamin d, retinoid x receptors, receptors, calcitriol, radioimmunoassay, oligonucleotide array sequence analysis, tissue array analysis, immunohistochemistry, logistic models, risk factors, case-control studies, follow-up studies, prospective studies, adult, aged, middle aged, female
8 authors
From US
- A. Heather Eliassen · correspondingBrigham and Women's Hospital; Harvard University
- Erica T. WarnerMassachusetts General Hospital
- BERNARD A. ROSNERBrigham and Women's Hospital; Harvard University; Cancer Research And Biostatistics
- Laura C. CollinsBeth Israel Deaconess Medical Center
- Andrew H. BeckBeth Israel Deaconess Medical Center
- Liza M. QuintanaBeth Israel Deaconess Medical Center
Abstract
Experimental evidence supports a protective role of 25-hydroxyvitamin D [25(OH)D] in breast carcinogenesis, but epidemiologic evidence is inconsistent. Whether plasma 25(OH)D interacts with breast tumor expression of vitamin D receptor (VDR) and retinoid X receptor-α (RXR) has not been investigated. We conducted a nested case-control study in the Nurses' Health Study, with 1,506 invasive breast cancer cases diagnosed after blood donation in 1989-1990, 417 of whom donated a second sample in 2000-2002. VDR and RXR expression were assessed by immunohistochemical staining of tumor microarrays (n = 669 cases). Multivariate relative risks (RR) and 95% confidence intervals (CI) were calculated using conditional logistic regression. Plasma 25(OH)D levels were not associated with breast cancer risk overall [top (≥32.7 ng/mL) vs. bottom (<17.2 ng/mL) quintile RR = 0.87; 95% CI, 0.67-1.13; P trend = 0.21]. 25(OH)D measured in summer (May-October) was significantly inversely associated with risk (top vs. bottom quintile RR = 0.66; 95% CI, 0.46-0.94; P trend = 0.01); winter levels (November-April) were not (RR = 1.10; 95% CI, 0.75-1.60; P trend = 0.64; P interaction = 0.03). 25(OH)D levels were inversely associated with risk of tumors with high expression of stromal nuclear VDR [≥30 ng/mL vs. <30 ng/mL RR (95% CI): VDR ≥ median = 0.67 (0.48-0.93); VDR < median = 0.98 (0.72-1.35), P heterogeneity = 0.12] and significantly stronger for summer measures (P heterogeneity = 0.01). Associations were not significantly different by RXR expression. No overall association was observed between plasma 25(OH)D and breast cancer risk. However, our results suggest women with high, compared with low, plasma 25(OH)D levels in the summer have a reduced breast cancer risk, and plasma 25(OH)D may be inversely associated with risk of tumors expressing high levels of VDR. Cancer Res; 76(18); 5423-30. ©2016 AACR.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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