Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis
Yassine HN, Feng Q, Azizkhanian I, Rawat V, Castor K, Fonteh AN, Harrington MG, Zheng L, Reed BR, DeCarli C, Jagust WJ, Chui HC
JAMA neurology · 69 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-08-17 · JAMA Neurol · vol. 73 · issue 10 · p. 1208
- Publisher
- American Medical Association
- Cited
- 93 citations · more than 99% of similar papers · 10.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 59 works
- Access
- Free to read
- Research areas
- Fatty Acid Research and Health · Peroxisome Proliferator-Activated Receptors · Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- Docosahexaenoic acid, Internal medicine, Amyloidosis, Pittsburgh compound B, Medicine, Amyloid (mycology), Endocrinology, Fatty acid, Alzheimer's disease, Physiology, Gastroenterology, Disease, Polyunsaturated fatty acid, Pathology, Biology, Biochemistry
- MeSH
- humans, brain diseases, alzheimer disease, amyloidosis, aniline compounds, thiazoles, docosahexaenoic acids, positron-emission tomography, cross-sectional studies, aged, aged, 80 and over, female, male, amyloid beta-peptides
12 authors
From US
- Hussein N. Yassine · correspondingUniversity of Southern California
- Qingru FengUniversity of Southern California
- Ida AzizkhanianUniversity of Southern California
- Varun RawatUniversity of Southern California
- Katherine CastorHuntington Medical Research Institutes
- Alfred Nji FontehHuntington Medical Research Institutes
Abstract
Importance
Higher dietary intake of the essential fatty acid docosahexaenoic (DHA) has been associated with better cognitive performance in several epidemiological studies. Animal and in vitro studies also indicate that DHA prevents amyloid deposition in the brain.
Objective
To determine the association between serum DHA levels, cerebral amyloidosis, and the volumes of brain areas affected by Alzheimer disease.
Design, settings, and participants
Cross-sectional analysis of serum DHA levels together with measures of amyloid deposition (Pittsburgh Compound B index), brain volumes, and neuropsychological testing scores from 61 participants in the Aging Brain Study. The study was conducted between June 2008 and May 2013, and the data were analyzed between October 2015 and April 2016. Linear models were adjusted for age, sex, years of education, and apolipoprotein E status.
Main outcomes and measures
Serum DHA levels with cerebral amyloidosis measured using PIB PET.
Results
Samples were available from 61 Aging Brain Study participants (41 women and 20 men) who underwent amyloid PET imaging. The mean (SD) age of the participants was 77 (6) years and ranged from 67 to 88 years. Serum DHA levels (percentage of total fatty acids) were 23% lower in participants with cerebral amyloidosis than those without (0.97 vs 1.25, P = .007) and were inversely correlated with brain amyloid load (r = -0.32, P = .01) independent of age, sex, apolipoprotein E genotype, and years of education. Moreover, greater serum DHA levels were positively associated with brain volume in several subregions affected by AD, in particular the left subiculum (r = 0.38, P = .005) and the left entorhinal volumes (r = 0.51, P = .001). Serum DHA levels were also associated with nonverbal memory scores (r = 0.28, P = .03).
Conclusions and relevance
In this study, serum DHA levels were associated with pathogenesis of cerebral amyloidosis and with preservation of entorhinal and hippocampal volumes. These findings suggest an important role for DHA metabolism in brain amyloid deposition during the preclinical or early symptomatic stages of Alzheimer disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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