Consumption of whole grains in relation to mortality from all causes, cardiovascular disease, and diabetes: Dose-response meta-analysis of prospective cohort studies
Li B, Zhang G, Tan M, Zhao L, Jin L, Tang X, Jiang G, Zhong K
Medicine · 37 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2016-08-01 · Medicine (Baltimore) · vol. 95 · issue 33 · p. e4229
- Publisher
- Wolters Kluwer
- Cited
- 57 citations · more than 94% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY-ND
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Keywords
- Medicine, Cohort study, Diabetes mellitus, Relative risk, Prospective cohort study, Internal medicine, Meta-analysis, Observational study, Cohort, Confidence interval, Stroke (engine), Endocrinology
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, diet, mortality, risk factors, prospective studies, dose-response relationship, drug, stroke, whole grains
8 authors
From CN
- Bailing LiSecond Military Medical University; Changhai Hospital
- Guanxin ZhangSecond Military Medical University; Changhai Hospital
- Mengwei TanSecond Military Medical University; Changhai Hospital
- Libo ZhaoSecond Military Medical University; Changhai Hospital
- Lei JinSecond Military Medical University; Changhai Hospital
- Xiaojun TangSecond Military Medical University; Changhai Hospital
Abstract
Background
To investigate the correlation between consumption of whole grains and the risk of all-cause, cardiovascular disease (CVD), and diabetes-specific mortality according to a dose-response meta-analysis of prospective cohort studies.
Methods
Observational cohort studies, which reported associations between whole grains and the risk of death outcomes, were identified by searching articles in the MEDLINE, EMBASE, and the reference lists of relevant articles. The search was up to November 30, 2015. Data extraction was performed by 2 independent investigators, and a consensus was reached with involvement of a third.
Results
Ten prospective cohort studies (9 publications) were eligible in this meta-analysis. During follow-up periods ranging from 5.5 to 26 years, there were 92,647 deaths among 782,751 participants. Overall, a diet containing greater amounts of whole grains may be associated with a lower risk of all-cause, CVD-, and coronary heart disease (CHD)-specific mortality. The summary relative risks (RRs) were 0.93 (95% confidence intervals [CIs]: 0.91-0.95; Pheterogeneity < 0.001) for all-cause mortality, 0.95 (95% CIs: 0.92-0.98; Pheterogeneity < 0.001) for CVD-specific mortality, and 0.92 (95% CIs: 0.88-0.97; Pheterogeneity < 0.001) for CHD-specific mortality for an increment of 1 serving (30 g) a day of whole grain intake. The combined estimates were robust across subgroup and sensitivity analyses. Higher consumption of whole grains was not appreciably associated with risk of mortality from stroke and diabetes.
Conclusion
Evidence from observational cohort studies indicates inverse associations of intake of whole grains with risk of mortality from all-cause, CVD, and CHD. However, no associations with risk of deaths from stroke and diabetes were observed.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-ND).
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