A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease
Vijayakumar M, Vasudevan DM, Sundaram KR, Krishnan S, Vaidyanathan K, Nandakumar S, Chandrasekhar R, Mathew N
Indian heart journal · 50 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2016-01-14 · Indian Heart J · vol. 68 · issue 4 · pp. 498–506
- Publisher
- Elsevier BV
- Cited
- 89 citations · more than 91% of similar papers · 2.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Coconut Research and Applications · Nuts composition and effects · Fatty Acid Research and Health
- Keywords
- Medicine, Sunflower oil, Coconut oil, Coronary artery disease, Anthropometry, Lipid profile, Fish oil, Saturated fat, Internal medicine, Food science, Cholesterol, Cardiology, Pathology, Biology
- MeSH
- humans, coronary disease, lipids, dietary fats, plant oils, incidence, follow-up studies, pilot projects, single-blind method, time factors, middle aged, india, female, male, sunflower oil, coconut oil
8 authors
From IN
- Maniyal Vijayakumar · correspondingAmrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- DM VasudevanAmrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- K. R. SundaramAmrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- Sajitha KrishnanAmrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- Kannan VaidyanathanInstitute of Medical Sciences
- Sandya NandakumarAmrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
Abstract
Background and rationale
Coronary artery disease (CAD) and its pathological atherosclerotic process are closely related to lipids. Lipids levels are in turn influenced by dietary oils and fats. Saturated fatty acids increase the risk for atherosclerosis by increasing the cholesterol level. This study was conducted to investigate the impact of cooking oil media (coconut oil and sunflower oil) on lipid profile, antioxidant mechanism, and endothelial function in patients with established CAD.
Design and methods
In a single center randomized study in India, patients with stable CAD on standard medical care were assigned to receive coconut oil (Group I) or sunflower oil (Group II) as cooking media for 2 years. Anthropometric measurements, serum, lipids, Lipoprotein a, apo B/A-1 ratio, antioxidants, flow-mediated vasodilation, and cardiovascular events were assessed at 3 months, 6 months, 1 year, and 2 years.
Results
Hundred patients in each arm completed 2 years with 98% follow-up. There was no statistically significant difference in the anthropometric, biochemical, vascular function, and in cardiovascular events after 2 years.
Conclusion
Coconut oil even though rich in saturated fatty acids in comparison to sunflower oil when used as cooking oil media over a period of 2 years did not change the lipid-related cardiovascular risk factors and events in those receiving standard medical care.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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