Maternal creatine in pregnancy: a retrospective cohort study
Dickinson H, Davies-Tuck M, Ellery SJ, Grieger JA, Wallace EM, Snow RJ, Walker DW, Clifton VL
BJOG : an international journal of obstetrics and gynaecology · 25 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Adelaide
Based on 1 listed funder(s).
Publication
- Published
- 2016-08-23 · BJOG · vol. 123 · issue 11 · pp. 1830–1838
- Publisher
- Wiley
- Cited
- 27 citations · more than 80% of similar papers · 1.5× the field average
- References
- 26 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Folate and B Vitamins Research · Gestational Diabetes Research and Management
- Keywords
- Creatine, Medicine, Pregnancy, Urine, Cohort, Prospective cohort study, Obstetrics, Urinary system, Gestation, Body mass index, Internal medicine, Fetus, Retrospective cohort study, Cohort study, Endocrinology, Biology
- MeSH
- humans, asthma, pregnancy complications, birth weight, creatine, linear models, retrospective studies, prospective studies, smoking, parity, fetal development, gestational age, pregnancy, pregnancy trimesters, social class, adult, infant, newborn, biological specimen banks, female
8 authors
From AU
- Hayley Dickinson · correspondingHudson Institute of Medical Research; Monash University
- Miranda L. Davies-TuckHudson Institute of Medical Research; Monash University
- Stacey J. ElleryHudson Institute of Medical Research; Monash University
- JA GriegerThe University of Adelaide
- Euan Morrison WallaceHudson Institute of Medical Research; Monash University
- RJ SnowDeakin University
Abstract
Objective
To estimate creatine concentrations in maternal plasma and urine, and establish relationships with maternal characteristics, diet and fetal growth.
Design
Retrospective cohort study.
Setting
Lyell McEwin Hospital, Adelaide, Australia.
Population
A biobank of plasma and urine samples collected at 13, 18, 30 and 36 weeks' gestation from 287 pregnant women from a prospective cohort of asthmatic and non-asthmatic women.
Methods
Creatine was measured by enzymatic analysis. Change in creatine over pregnancy was assessed using the Friedman test. Linear mixed models regression was used to determine associations between maternal factors and diet with creatine across pregnancy and between creatine with indices of fetal growth at birth.
Main outcome measures
Maternal creatine concentrations, associations between maternal factors and creatine and between creatine and fetal growth parameters.
Results
Maternal smoking, body mass index, asthma and socio-economic status were positively and parity negatively associated with maternal plasma and/or urine creatine. Maternal urine creatine concentration was positively associated with birthweight centile and birth length. After adjustment, each μmol/l increase in maternal urinary creatine was associated with a 1.23 (95% CI 0.44-2.02) unit increase in birthweight centile and a 0.11-cm (95% CI 0.03-0.2) increase in birth length.
Conclusions
Maternal factors and fetal growth measures are associated with maternal plasma and urine creatine concentrations.
Tweetable abstract
Maternal creatine is altered by pregnancy; fetal growth measures are associated with maternal creatine concentrations.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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