Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men
Ostojic SM, Ostojic J, Drid P, Vranes M
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 31 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-06-13 · Appl Physiol Nutr Metab · vol. 41 · issue 9 · pp. 1005–1007
- Publisher
- NRC Research Press
- Cited
- 51 citations · more than 87% of similar papers · 2.4× the field average
- References
- 20 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Folate and B Vitamins Research · HIV-related health complications and treatments
- Keywords
- Creatine, Crossover study, Creatine Monohydrate, Medicine, Bioenergetics, Phosphocreatine, Internal medicine, Endocrinology, Energy metabolism, Placebo, Chemistry, Biochemistry, Pathology
- MeSH
- frontal lobe, neurons, humans, hyperhomocysteinemia, creatine, homocysteine, glycine, magnetic resonance spectroscopy, follow-up studies, pilot projects, cross-over studies, double-blind method, up-regulation, dietary supplements, adult, male, quadriceps muscle, serbia, young adult, performance-enhancing substances, middle cerebellar peduncle, biomarkers
4 authors
From RS
- Sergej M. OstojićUniversity of Novi Sad; University of Belgrade
- Jelena Nesovic OstojicKlinički centar Vojvodine
- Patrik DridUniversity of Novi Sad
- Milan VranešUniversity of Novi Sad
Abstract
In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.