Fish oil supplements, longevity and aging
de Magalhães JP, Müller M, Rainger GE, Steegenga W
Aging · 29 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Wellcome Trust
- Nonprofit
- Methuselah Foundation
- Nonprofit
- British Heart Foundation
- Government
- Biotechnology and Biological Sciences Research Council
- Grants
- British Heart Foundation (RG/12/7/29693); British Heart Foundation (FS/14/42/30956); British Heart Foundation (PG/09/069/27905); British Heart Foundation (PG/11/49/28983); Biotechnology and Biological Sciences Research Council (BBS/B/01057)
Based on 4 listed funder(s).
Publication
- Published
- 2016-08-25 · Aging (Albany NY) · vol. 8 · issue 8 · pp. 1578–1582
- Publisher
- Impact Journals LLC
- Cited
- 48 citations · more than 90% of similar papers · 2.8× the field average
- References
- 46 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Fatty Acid Research and Health · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Docosahexaenoic acid, Fish oil, Polyunsaturated fatty acid, Eicosapentaenoic acid, Food science, Biology, Fatty acid, Biochemistry, Fish <Actinopterygii>, Fishery
- MeSH
- animals, humans, mice, fish oils, antioxidants, longevity, dietary supplements, female, male, nf-e2-related factor 2, glycoside hydrolase inhibitors
4 authors
From GB, NL
- João Pedro de MagalhãesUniversity of Liverpool
- Michael MüllerNorwich Research Park
- G. Ed RaingerUniversity of Birmingham
- Wilma T. SteegengaWageningen University & Research
Abstract
Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can increase lifespan, affecting pathways like inflammation and oxidation thought to be involved in the regulation of aging. Could fish oil and its omega-3 fatty acids act as geroprotectors? Probably not. A new study by Strong et al. challenges the role for fish oil supplementation in aging. Using a large cohort of genetically heterogeneous mice in three sites, part of the Interventions Testing Program of the NIA, Strong et al. show that fish oil supplementation at either low or high dosages has no effect on the lifespan of male or female mice. Although it is still possible that fish oil supplementation has health benefits for specific age-related diseases, it does not appear to slow aging or have longevity benefits.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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