Association between whole grain intake and all-cause mortality: a meta-analysis of cohort studies
Ma X, Tang WG, Yang Y, Zhang QL, Zheng JL, Xiang YB
Oncotarget · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-08-22 · Oncotarget · vol. 7 · issue 38 · pp. 61996–62005
- Publisher
- Impact Journals LLC
- Cited
- 25 citations · more than 61% of similar papers · 0.7× the field average
- References
- 64 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Nutritional Studies and Diet · Nutrition and Health in Aging · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Meta-analysis, Confidence interval, Epidemiology, Relative risk, Cohort study, Demography, Prospective cohort study, Cohort, Observational study, Biostatistics, Gerontology, Internal medicine
- MeSH
- humans, body mass index, exercise, diet, mortality, risk factors, regression analysis, follow-up studies, prospective studies, feeding behavior, alcohol drinking, adult, aged, aged, 80 and over, middle aged, female, male, whole grains
6 authors
From CN, US
- Xiao Ma · correspondingRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Wei‐Guo Tang · correspondingRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Yang YangRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Qingli ZhangRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Jiali ZhengUniversity of South Carolina
- Yong‐Bing XiangRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
Abstract
Some observational studies have examined the association between dietary whole grain intake and all-cause mortality, but the results were inconclusive. We therefore conducted a meta-analysis to summarize the evidence from cohort studies regarding the association between whole grain intake and all-cause mortality. Pertinent studies were identified by searching PubMed, Embase and Web of Knowledge, up to February 28, 2016. Study-specific estimates were combined using random-effects models. Eleven prospective cohort studies involving 101,282 deaths and 843,749 participants were included in this meta-analysis. The pooled relative risk of all-cause mortality for the highest category of whole grain intake versus lowest category was 0.82 (95% confidence interval: 0.78, 0.87). There was a 7% reduction in risk associated with each 1 serving/day increase in whole grain intake (relative risk = 0.93; 95% confidence interval: 0.89, 0.97). No publication bias was found. This analysis indicates that higher intake of whole grain is associated with a reduced risk of all-cause mortality. The findings support current recommendations for increasing whole grain consumption to promote health and overall longevity.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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