A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity
Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL, Troy Donahoo W
Obesity (Silver Spring, Md.) · 243 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- National Center for Complementary and Integrative Health
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NIDDK NIH HHS
- Government
- NCATS NIH HHS
- Government
- NICHD NIH HHS
- Government
- NCCIH NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK048520); Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50 HD073063); National Center for Advancing Translational Sciences (UL 1 TR001082); National Center for Complementary and Integrative Health (R21 AT002617); National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK067403); National Institutes of Health (UL1-TR-001082); National Institutes of Health (TR001082); National Institutes of Health (NIH UL1 TR001082); National Institutes of Health (R21 AT002617‐02); National Institutes of Health (R21 AT002617‐02, NIH UL1 TR001082, NIH DK 048520); National Institutes of Health (NIH-DK048520)
Based on 10 listed funder(s).
Publication
- Published
- 2016-08-29 · Obesity (Silver Spring) · vol. 24 · issue 9 · pp. 1874–1883
- Publisher
- Wiley
- Cited
- 338 citations · more than 99% of similar papers · 9.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Diet and metabolism studies
- Keywords
- Caloric theory, Calorie, Medicine, Low calorie diet, Obesity, Caloric intake, Randomized controlled trial, Calorie restriction, Gerontology, Weight loss, Internal medicine
- MeSH
- humans, obesity, body weight, weight loss, treatment outcome, caloric restriction, diet, reducing, fasting, pilot projects, body composition, energy intake, adult, middle aged, female, male
10 authors
From US
- Victoria A. Catenacci · correspondingColorado School of Public Health; University of Colorado Anschutz
- Zhaoxing PanChildren's Hospital Colorado; University of Colorado Anschutz; University of Colorado Denver
- Danielle M. OstendorfColorado School of Public Health; University of Colorado Anschutz
- Sarah BrannonColorado School of Public Health; University of Colorado Anschutz
- Wendolyn S. GozanskyKaiser Permanente
- Mark P. MattsonNational Institutes of Health; Johns Hopkins University; Johns Hopkins Medicine; Institute on Aging; National Institute on Aging
Abstract
Objective
To evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR).
Methods
Adults with obesity (BMI ≥30 kg/m(2) , age 18-55) were randomized to either zero-calorie ADF (n = 14) or CR (-400 kcal/day, n = 12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up.
Results
No adverse effects were attributed to ADF, and 93% completed the 8-week ADF protocol. At 8 weeks, ADF achieved a 376 kcal/day greater energy deficit; however, there were no significant between-group differences in change in weight (mean ± SE; ADF -8.2 ± 0.9 kg, CR -7.1 ± 1.0 kg), body composition, lipids, or Si. After 24 weeks of unsupervised follow-up, there were no significant differences in weight regain; however, changes from baseline in % fat mass and lean mass were more favorable in ADF.
Conclusions
ADF is a safe and tolerable approach to weight loss. ADF produced similar changes in weight, body composition, lipids, and Si at 8 weeks and did not appear to increase risk for weight regain 24 weeks after completing the intervention.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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