Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry
Feliciano RP, Istas G, Heiss C, Rodriguez-Mateos A
Molecules (Basel, Switzerland) · 59 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- No health outcome
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2016-08-25 · Molecules · vol. 21 · issue 9 · p. 1120
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 83 citations · more than 96% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Antioxidant Activities · Biochemical Analysis and Sensing Techniques · Tea Polyphenols and Effects
- Keywords
- Hippuric acid, Urine, Chemistry, Polyphenol, Phenols, Urinary system, Excretion, Food science, Internal medicine, Medicine, Biochemistry, Antioxidant
- MeSH
- humans, fruit, double-blind method, eating, adolescent, adult, aged, middle aged, male, polyphenols, gastrointestinal microbiome, blueberry plants
4 authors
From DE
- Rodrigo Pedro FelicianoHeinrich Heine University Düsseldorf
- Geoffrey IstasHeinrich Heine University Düsseldorf
- Christian HeißHeinrich Heine University Düsseldorf
- Ana Rodriguez‐Mateos · correspondingHeinrich Heine University Düsseldorf
Abstract
Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at baseline and 2 h post-consumption on day 1 and day 30. Twenty-four-hour urine was also collected on both days. A total of 61 phenolic metabolites were quantified in plasma at baseline, of which 43 increased after acute or chronic consumption of blueberries over one month. Benzoic and catechol derivatives represented more than 80% of the changes in phenolic profile after 2 h consumption on day 1, whereas hippuric and benzoic derivatives were the major compounds that increased at 0 and 2 h on day 30, respectively. The total (poly)phenol urinary excretion remained unchanged after 30 days of wild blueberry intake. The inter-individual variability ranged between 40%-48% in plasma and 47%-54% in urine. Taken together, our results illustrate that blueberry (poly)phenols are absorbed and extensively metabolized by phase II enzymes and by the gut microbiota, leading to a whole array of metabolites that may be responsible for the beneficial effects observed after blueberry consumption.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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