25 Hydroxyvitamin D Deficiency and Its Relationship to Autoimmune Thyroid Disease in the Elderly
Muscogiuri G, Mari D, Prolo S, Fatti LM, Cantone MC, Garagnani P, Arosio B, Di Somma C, Vitale G
International journal of environmental research and public health · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-08-26 · Int J Environ Res Public Health · vol. 13 · issue 9 · p. 850
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 55 citations · more than 92% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Bone health and osteoporosis research
- Keywords
- Medicine, Thyroid disease, Thyroid, Autoimmune disease, Graves' disease, Disease, Internal medicine
- MeSH
- humans, vitamin d deficiency, thyroiditis, autoimmune, thyrotropin, triiodothyronine, thyroxine, iodide peroxidase, vitamin d, iron-binding proteins, thyroglobulin, autoantibodies, autoantigens, aged, aged, 80 and over, female, male
9 authors
From IT
- Giovanna Muscogiuri
- Daniela MariUniversity of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Silvia ProloUniversity of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; University of Milano-Bicocca
- Letizia Maria FattiIRCCS Istituto Auxologico Italiano
- Maria Celeste CantoneUniversity of Milan
- Paolo GaragnaniUniversity of Bologna
Abstract
Background
Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroiditis (AT). The aim of the study was to investigate the association of AT with low 25(OH) vitamin D levels in the elderly.
Methods
One hundred sixty-eight elderly subjects (mean age: 81.6 ± 9.4 years) were enrolled. Serum levels of 25(OH) vitamin D, anti-thyroid peroxidase (TPO-Ab), anti-thyroglobulin (TG-Ab) antibodies, free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measured.
Results
The prevalence of AT was significantly higher in subjects with vitamin D deficiency (25(OH) vitamin D < 20 ng/mL) when compared with subjects with normal 25(OH) vitamin D (25(OH) vitamin D ≥ 20 ng/mL) levels (28% vs. 8%, respectively, p = 0.002). Patients with AT and vitamin D deficiency had a comparable hormonal profile compared to patients with AT and vitamin D sufficiency in terms of TSH (p = 0.39), FT3 (p = 0.30), FT4 (p = 0.31), TG-Ab (0.44) and TPO-Ab (0.35). Interestingly, a significant correlation between 25(OH) vitamin D and TPO-Ab (r = -0.27, p = 0.03) and FT3 (r = 0.35, p = 0.006) has been found in subjects with AT while no correlation was found between 25(OH) vitamin D levels and TG-Ab (r = -0.15, p = 0.25), TSH (r = -0.014, p = 0.09) and FT4 (r = 0.13, p = 0.32).
Conclusions
These findings suggest that vitamin D deficiency was significantly associated with AT in the elderly. Therefore, the screening for AT should be suggested in subjects with vitamin D deficiency.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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