Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial
Fard FE, Mirghafourvand M, Mohammad-Alizadeh Charandabi S, Farshbaf-Khalili A, Javadzadeh Y, Asgharian H
Women & health · 42 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Tabriz University of Medical Sciences
- Grants
- Tabriz University of Medical Sciences (93106)
Based on 1 listed funder(s).
Publication
- Published
- 2016-09-12 · Women Health · vol. 57 · issue 9 · pp. 1115–1128
- Publisher
- Routledge
- Cited
- 60 citations · more than 96% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Paywalled
- Research areas
- Maternal Mental Health During Pregnancy and Postpartum · Pregnancy and Medication Impact · Magnesium in Health and Disease
- Keywords
- Placebo, Anxiety, Postpartum depression, Medicine, Magnesium, Randomized controlled trial, Edinburgh Postnatal Depression Scale, Depression (economics), Postpartum period, Internal medicine, Obstetrics, Depressive symptoms, Psychiatry, Pregnancy, Chemistry, Alternative medicine
- MeSH
- humans, depression, postpartum, magnesium sulfate, zinc sulfate, treatment outcome, anxiety, psychiatric status rating scales, postpartum period, pregnancy, dietary supplements, adult, female
6 authors
From IR
- Fatemeh Edalati FardTabriz University of Medical Sciences
- Mojgan Mirghafourvand · correspondingTabriz University of Medical Sciences
- Sakineh Mohammad‐Alizadeh‐CharandabiTabriz University of Medical Sciences
- Azizeh Farshbaf‐KhaliliTabriz University of Medical Sciences
- Yousef JavadzadehTabriz University of Medical Sciences
- Hanieh AsgharianTabriz University of Medical Sciences
Abstract
Postpartum anxiety and depression are prevalent disorders. The authors of this study aimed to determine the effects of zinc and magnesium supplements on depressive symptoms and anxiety in postpartum women referred to three governmental, educational hospitals in Tabriz, Iran during 2014-2015. In this triple-blind, randomized, controlled clinical trial, the participants were randomly assigned to the zinc sulfate, magnesium sulfate, and placebo groups (n = 33 per group). The intervention groups received a 27-mg zinc sulfate tablet or 320-mg magnesium sulfate tablet per day for 8 weeks, whereas the control group received a placebo tablet each day during the same period. The Edinburgh Postnatal Depression Scale and the Spielberger State-Trait Anxiety Inventory were completed before and 8 weeks after the intervention. Blood samples were drawn from each participant to determine serum levels of zinc and magnesium before intervention at 48 hours after delivery. Also, a 24-hour dietary questionnaire was used during the first and last 3 days of the intervention. Adjusting for baseline scores as well as zinc and magnesium serum levels, no significant difference was observed between groups 8 weeks after delivery in mean scores of depressive symptoms (p = .553), state anxiety (p = .995), and trait anxiety (p = .234). This study concluded magnesium and zinc did not reduce postpartum anxiety and depressive symptoms.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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