Dietary Nitrate Acutely and Markedly Increased Exhaled Nitric Oxide in a Cystic Fibrosis Case
Kerley CP, Kilbride E, Greally P, Elnazir B
Clinical medicine & research · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-09-14 · Clin Med Res · vol. 14 · issue 3-4 · pp. 151–155
- Publisher
- Marshfield Clinic
- Cited
- 13 citations · more than 70% of similar papers · 0.5× the field average
- References
- 19 works
- Access
- Open access (free to publish)
- Research areas
- Cystic Fibrosis Research Advances · Neonatal Respiratory Health Research · Respiratory Support and Mechanisms
- Keywords
- Exhaled nitric oxide, Nitric oxide, Cystic fibrosis, Medicine, Nitrite, Nitrate, Exhaled air, Ingestion, Internal medicine, Airway, Gastroenterology, Fibrosis, Lung, Lung function, Anesthesia, Biology, Toxicology
- MeSH
- humans, cystic fibrosis, inflammation, nitrates, nitrites, iron, nitric oxide, arginine, placebos, respiratory function tests, treatment outcome, diet, exhalation, child, male
4 authors
From IE
- Conor P. Kerley · correspondingUniversity College Dublin; National Children’s Research Centre
- Emma KilbrideNational Children’s Research Centre
- Peter GreallyNational Children’s Research Centre
- Basil ElnazirNational Children’s Research Centre
Abstract
Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12-year-old, athletic boy with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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