Cholecalciferol treatment downregulates renin-angiotensin system and improves endothelial function in essential hypertensive patients with hypovitaminosid D
Carrara D, Bruno RM, Bacca A, Taddei S, Duranti E, Ghiadoni L, Bernini G
Journal of hypertension · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-09-20 · J Hypertens · vol. 34 · issue 11 · pp. 2199–2205
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 37 citations · more than 92% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 64 works
- Access
- Paywalled
- Research areas
- Vitamin D Research Studies · Cardiovascular Health and Disease Prevention · Cardiovascular Disease and Adiposity
- Keywords
- Medicine, Internal medicine, Endocrinology, Cholecalciferol, Aldosterone, Vitamin D and neurology, Plasma renin activity, Renin–angiotensin system, Angiotensin II, Vasodilation, Brachial artery, Essential hypertension, Blood pressure
- MeSH
- endothelium, humans, cardiovascular diseases, hypertension, vitamin d deficiency, cholecalciferol, aldosterone, renin, vitamins, vitamin d, angiotensin ii, renin-angiotensin system, blood pressure, vasodilation, adult, middle aged, female, male, pulse wave analysis, essential hypertension
7 authors
From IT, US
- Davide CarraraUniversity of Pisa; May Institute
- Rosa María BrunoUniversity of Pisa; May Institute
- Alessandra BaccaUniversity of Pisa; May Institute
- Stefano TaddeiUniversity of Pisa; May Institute
- Emiliano DurantiUniversity of Pisa; May Institute
- Lorenzo GhiadoniUniversity of Pisa; May Institute
Abstract
Background
Vitamin D deficiency is related to an increased prevalence of cardiovascular disease. Renin-angiotensin-aldosterone system suppression and vascular dysfunction are considered among the main mechanisms implicated in this association. However, interventional studies demonstrating that vitamin D replacement reduces circulating renin-angiotensin-aldosterone components and improves vascular function in humans are still lacking.
Methods
Thirty-three consecutive patients with essential hypertension and hypovitaminosis D underwent therapy with cholecalciferol 50 000 IU/week orally for 8 weeks. Thirty-three hypertensive patients with normal vitamin D levels and 20 normotensive individuals were also enrolled as control groups. At baseline and at the end of the study, we evaluated plasma renin activity, circulating renin, angiotensin II, aldosterone and plasma vitamin D levels. Endothelial function [flow-mediated dilation (FMD)], carotid-femoral pulse wave velocity and augmentation index, peripheral and central blood pressure were also acquired.
Results
After 8-week cholecalciferol administration, all treated patients normalized plasma 25(OH)D values. Furthermore, a reduction in plasma levels of plasma renin activity (1.17 ± 0.3 vs 1.51 ± 0.4 ng/ml per h, P = 0.02), renin (13.4 ± 1.7 vs 19.2 ± 2.9 pg/ml, P < 0.001), angiotensin II (11.6 ± 1.6 vs 15.8 ± 2.7 pg/ml, P = 0.02) was observed at the end of the study. FMD was significantly increased after cholecalciferol treatment (4.4 ± 2.6 vs 3.3 ± 2.1%, P < 0.05), in the absence of changes of brachial artery diameter and endothelium-independent vasodilation. Carotid-femoral pulse wave velocity and augmentation index were not modified, as well peripheral and central blood pressure.
Conclusion
The restoration of normal vitamin D levels after 8-week cholecalciferol treatment is able to inhibit peripheral renin-angiotensin system and improve FMD in essential hypertensive patients with hypovitaminosis D.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.